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CVD and Metabolic Complications of HIV/AIDS Data Coordinating Center

HIV/AIDS数据协调中心的CVD和代谢并发症

基本信息

批准号：
7691227
负责人：
Elizabeth Renata Brown
金额：
$ 100.12万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-25 至 2013-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7691227
关键词：
AIDS/HIV problem Address Area Biological Markers Calcium Cardiac Cardiovascular Diseases Cardiovascular system Clinic Visits Communication Coronary Coronary Arteriosclerosis Data Data Analyses Data Collection Data Coordinating Center Databases Development Directories Disease Documentation Ensure Evaluation Exposure to Fostering Funding Opportunities Goals HIV HIV Infections Health Highly Active Antiretroviral Therapy Incidence Individual Life Life Expectancy Manuscripts Medical Metabolic Methodology National Heart, Lung, and Blood Institute Nature Patients Play Preparation Protocols documentation Publications Published Directory Randomized Readiness Reading Reporting Research Research Activity Research Design Research Personnel Resources Role Running Sample Size Schedule Scheme Site Specimen Standardization Universities Washington Writing abstracting cardiovascular disorder risk cardiovascular risk factor clinical research site data integration design disorder risk experience imaging modality meetings novel prevent programs protocol development repository response symposium tool treatment strategy web site

项目摘要

DESCRIPTION (provided by applicant): This proposal is written in response to an NHLBI FOA requesting a Data Coordinating Center (DCC) for RFA-HL-08-003 Mechanisms and Management of Cardiovascular and Metabolic Complications of HIV/AIDS. The purpose of the FOA is to foster collaborative research to elucidate the underlying mechanisms of metabolic and anthropometric abnormalities seen in HIV infection and highly active antiretroviral therapy and their relationship to cardiovascular disease risk. In this application, we propose to run the DCC from the Collaborative Health Studies Coordinating Center (CHSCC) at the University of Washington. The DCC will be responsible for coordinating studies at 6-7 clinical sites engaged in separate, but complimentary research agendas. Although the studies will all involve research that addresses the title of this RFA, the size and scope of these studies has yet to be fully determined. The DCC will play a key role in coordination and management of these studies. Its key responsibilities will include facilitation of data harmonization, standardization of study protocols where appropriate, facilitating data and specimen banking, scheduling and facilitating investigator meetings, coordinating centralized readings of cardiac evaluations and providing statistical expertise and support in protocol development, data analysis and preparation of presentations and manuscripts. This application describes our relevant experience and preparedness in these areas as well as others crucial to efficiently running a DCC. It also presents our plans for running the DCC for this group of studies. HIV-infected individuals have increased life expectancies since the introduction of highly active antiretroviral therapy (HAART). With this increased life expectancy come increased incidences of metabolic complications and cardiovascular disease (CVD) associated with living with HIV/AIDS and prolonged exposure to HAART. Studying how these diseases interact with HIV and HAART can help prevent their development and progression in HIV-infected individuals. (End of Abstract)

描述（由申请人提供）：