CVD and Metabolic Complications of HIV/AIDS Data Coordinating Center

HIV/AIDS数据协调中心的CVD和代谢并发症

• 批准号: 7881416
• 负责人: Elizabeth Renata Brown
• 金额: $ 98.53万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-25 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7881416
• 关键词: AIDS/HIV problem; Address; Area; Biological Markers; Calcium; Cardiac; Cardiovascular Diseases; Cardiovascular system; Clinic Visits; Communication; Coronary; Coronary Arteriosclerosis; Data; Data Analyses; Data Collection; Data Coordinating Center; Databases; Development; Directories; Disease; Documentation; Ensure; Evaluation; Exposure to; Fostering; Funding Opportunities; Goals; HIV; HIV Infections; Health; Highly Active Antiretroviral Therapy; Incidence; Individual; Life; Life Expectancy; Manuscripts; Medical; Metabolic; Methodology; National Heart, Lung, and Blood Institute; Nature; Patients; Play; Preparation; Protocols documentation; Publications; Published Directory; Randomized; Readiness; Reading; Reporting; Research; Research Activity; Research Design; Research Personnel; Resources; Role; Running; Sample Size; Schedule; Scheme; Site; Specimen; Standardization; Universities; Washington; Writing; abstracting; cardiovascular disorder risk; cardiovascular risk factor; clinical research site; data integration; design; disorder risk; experience; imaging modality; meetings; novel; prevent; programs; protocol development; repository; response; symposium; tool; treatment strategy; web site

DESCRIPTION (provided by applicant): This proposal is written in response to an NHLBI FOA requesting a Data Coordinating Center (DCC) for RFA-HL-08-003 Mechanisms and Management of Cardiovascular and Metabolic Complications of HIV/AIDS. The purpose of the FOA is to foster collaborative research to elucidate the underlying mechanisms of metabolic and anthropometric abnormalities seen in HIV infection and highly active antiretroviral therapy and their relationship to cardiovascular disease risk. In this application, we propose to run the DCC from the Collaborative Health Studies Coordinating Center (CHSCC) at the University of Washington. The DCC will be responsible for coordinating studies at 6-7 clinical sites engaged in separate, but complimentary research agendas. Although the studies will all involve research that addresses the title of this RFA, the size and scope of these studies has yet to be fully determined. The DCC will play a key role in coordination and management of these studies. Its key responsibilities will include facilitation of data harmonization, standardization of study protocols where appropriate, facilitating data and specimen banking, scheduling and facilitating investigator meetings, coordinating centralized readings of cardiac evaluations and providing statistical expertise and support in protocol development, data analysis and preparation of presentations and manuscripts. This application describes our relevant experience and preparedness in these areas as well as others crucial to efficiently running a DCC. It also presents our plans for running the DCC for this group of studies. HIV-infected individuals have increased life expectancies since the introduction of highly active antiretroviral therapy (HAART). With this increased life expectancy come increased incidences of metabolic complications and cardiovascular disease (CVD) associated with living with HIV/AIDS and prolonged exposure to HAART. Studying how these diseases interact with HIV and HAART can help prevent their development and progression in HIV-infected individuals. (End of Abstract)

描述（由申请人提供）： 本提案是为了响应NHLBI FOA要求建立RFA-HL-08 - 003 HIV/AIDS心血管和代谢并发症的机制和管理数据协调中心（DCC）而编写的。FOA的目的是促进合作研究，以阐明HIV感染和高效抗逆转录病毒治疗中出现的代谢和人体测量异常的潜在机制及其与心血管疾病风险的关系。在本申请中，我们建议从华盛顿大学的协作健康研究协调中心（CHSCC）运行DCC。DCC将负责协调6 - 7个临床研究中心的研究，这些研究中心从事单独但互补的研究议程。虽然这些研究都将涉及解决本RFA标题的研究，但这些研究的规模和范围尚未完全确定。发展协调委员会将在协调和管理这些研究方面发挥关键作用。其主要职责将包括促进数据统一，酌情使研究方案标准化，促进数据和样本库，安排和促进研究者会议，协调心脏评价的集中读数，并在方案制定、数据分析和编写演示文稿和手稿方面提供统计专业知识和支持。此应用程序描述了我们在这些领域的相关经验和准备，以及其他对高效运行DCC至关重要的方面。它还提出了我们的计划运行DCC为这组研究。自从采用高效抗逆转录病毒疗法以来，艾滋病毒感染者的预期寿命有所增加。随着预期寿命的增加，与艾滋病毒/艾滋病和长期接触HAART相关的代谢并发症和心血管疾病（CVD）的发病率也随之增加。研究这些疾病如何与艾滋病毒和HAART相互作用，可以帮助预防艾滋病毒感染者的发展和进展。(End摘要）