Restless Legs Syndrome, Cardiovascular Risk Factors, and Cardiovascular Events

不宁腿综合症、心血管危险因素和心血管事件

• 批准号: 7666751
• 负责人: Tobias Kurth
• 金额: $ 36.43万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7666751
• 关键词: Affect; Age; Age of Onset; Age-Years; Applications Grants; Ascorbic Acid; Aspirin; Benefits and Risks; Beta Carotene; Biochemical Markers; Biological; Biological Markers; Blood Pressure; Blood specimen; Cardiovascular Diseases; Cardiovascular system; Cataract; Cessation of life; Characteristics; Clinical; Cohort Studies; Coronary; Cross-Sectional Studies; Data Collection; Development; Diabetes Mellitus; Diagnostic; Diet Habits; Disease; Dose; Epidemiologic Studies; Esthesia; Event; Eye diseases; Family; Fatigue; Frequencies; Funding; Future; Health; Health Professional; High Prevalence; Hypertension; International; Left; Leg; Life; Life Style; Literature; Macular degeneration; Malignant Neoplasms; Malignant neoplasm of prostate; Measures; Medical History; Medical Records; Migraine; Multivitamin; Myocardial Infarction; Obesity; Occupational; Outcome; Participant; Patient Self-Report; Patients; Performance; Physicians; Population; Prevalence; Primary Prevention; Principal Investigator; Procedures; Publications; Publishing; Questionnaires; Randomized; Randomized Controlled Clinical Trials; Research; Restless Legs Syndrome; Risk; Risk Factors; Self-Administered; Sleep; Sleep Fragmentations; Smoke; Smoking; Stroke; Symptoms; Testing; Time; United States National Institutes of Health; Vitamin E; Woman; Women' s Health; age related; aged; base; cardiovascular disorder prevention; cardiovascular disorder risk; cardiovascular risk factor; case control; cohort; cost; deprivation; design; double-blind placebo controlled trial; exhaust; exhaustion; falls; follow-up; male; men; nervous system disorder; prospective; public health relevance; social

DESCRIPTION (provided by applicant): This is a resubmission of grant proposal R01 HL091880-01, "Restless Legs Syndrome, Cardiovascular Risk Factors, and Cardiovascular Disease." This proposal has three specific aims: 1) to evaluate the association between restless legs syndrome (RLS) and prevalent risk factors for cardiovascular disease (CVD); 2) to evaluate the association between RLS and prevalent overall and specific types of CVD; and 3) to evaluate the association between RLS and incident overall and specific types of CVD. RLS is a common neurological disorder characterized by unpleasant sensations of the legs and an urge to move them for relief. Because symptoms are intensified by inactivity and lying down, RLS patients are often sleep deprived, exhausted and fatigued. Occupational performance, social activities, and family life are severely impaired. Most prevalence estimates indicate that between 7% and 10% of the population suffers from RLS, although with different symptom frequencies. However, RLS is probably underdiagnosed. Despite the publication of the so-called minimal criteria for RLS in 1995 and their 2003 revision, which accelerated epidemiologic RLS research, still little is known about the onset and course of the disease and its consequences on a population level. Recently, it has been suggested that RLS is associated with a more unfavorable cardiovascular risk factor profile, including higher prevalences of smoking, hypertension, nocturnal blood pressure changes, and diabetes. Since these observations were made in cross-sectional studies, it is, however, unclear whether RLS is a cause or a consequence of an unfavorable risk factor profile. All of these CVD factors increase the risk of subsequent CVD events. Thus, it is plausible that RLS is not only associated with risk factors for CVD but also with subsequent CVD events. We propose to study these questions in three large-scale, well-characterized, prospective cohort studies of over 20,000 men (Physicians' Health Study I and II) and 33,000 women (Women's Health Study) with over 21, 9, and 12 years of follow-up, respectively. In all three studies, the minimal diagnostic criteria of the International RLS Study Group to ascertain RLS in epidemiologic studies were included in self-administered questionnaires. Since all studies were originally designed as primary prevention trials of CVD and cancer, information about these outcomes is excellent, and all events were confirmed by medical record review. Furthermore, all participants provided high-quality information about a large number of lifestyle habits, diet, medical history, and personal characteristics at baseline and during follow- up. Thus, these three prospective cohort studies of men and women provide a unique opportunity to study the interrelationships between RLS, risk factors for CVD, and CVD events. Since most information has already been collected and ongoing data collection is imbedded in ongoing NIH funded projects, we can propose to study these questions in a very cost-effective way. PUBLIC HEALTH RELEVANCE: About 10% of the population suffers from Restless Legs Syndrome (RLS), a neurological disorder characterized by unpleasant sensations of the legs and an urge to move them for relief. Recently, it has been suggested that RLS is associated with a more unfavorable risk profile for cardiovascular disease (CVD). Thus, the question arises as whether patients with RLS have not only a higher prevalence of CVD risk factors but whether they are also at increased risk for subsequent CVD events. Thus, this grant proposal request funding to study the association between RLS, CVD risk factors as well as CVD events.

描述（由申请人提供）：这是重新提交的资助提案R 01 HL 091880 -01，“不宁腿综合征，心血管危险因素和心血管疾病。该提案有三个具体目标：1）评估不宁腿综合征（RLS）与心血管疾病（CVD）流行危险因素之间的关联; 2）评估RLS与流行的整体和特定类型CVD之间的关联; 3）评估RLS与整体和特定类型CVD事件之间的关联。RLS是一种常见的神经系统疾病，其特征是腿部的不愉快感觉和移动它们以缓解的冲动。由于不活动和躺下会加剧症状，RLS患者通常睡眠不足，疲惫和疲劳。职业表现、社会活动和家庭生活严重受损。大多数患病率估计表明，7%至10%的人口患有RLS，尽管症状频率不同。然而，RLS可能诊断不足。尽管在1995年发表了所谓的RLS最低标准及其2003年修订版，加速了流行病学RLS研究，但对疾病的发病和病程及其在人群水平上的后果仍知之甚少。最近，研究表明RLS与更不利的心血管危险因素相关，包括吸烟、高血压、夜间血压变化和糖尿病的患病率较高。由于这些观察结果是在横断面研究中进行的，因此，目前还不清楚RLS是不利风险因素的原因还是结果。所有这些CVD因素都会增加随后CVD事件的风险。因此，RLS不仅与CVD的风险因素相关，而且与随后的CVD事件相关，这是合理的。我们建议在三项大规模、特征明确的前瞻性队列研究中研究这些问题，这些研究分别涉及20，000多名男性（医生健康研究I和II）和33，000名女性（女性健康研究），随访时间分别超过21年、9年和12年。在所有三项研究中，国际RLS研究组在流行病学研究中确定RLS的最低诊断标准包括在自填问卷中。由于所有研究最初均设计为CVD和癌症的一级预防试验，因此有关这些结局的信息非常好，所有事件均通过病历审查确认。此外，所有参与者在基线和随访期间提供了大量关于生活习惯、饮食、病史和个人特征的高质量信息。因此，这三项男性和女性前瞻性队列研究为研究RLS、CVD风险因素和CVD事件之间的相互关系提供了独特的机会。由于大多数信息已经收集，并且正在进行的数据收集嵌入到正在进行的NIH资助项目中，因此我们可以建议以非常具有成本效益的方式研究这些问题。公共卫生相关性：大约10%的人口患有不宁腿综合征（RLS），这是一种神经系统疾病，其特征是腿部的不愉快感觉和移动它们以缓解的冲动。最近，有研究表明RLS与心血管疾病（CVD）的更不利风险特征相关。因此，问题是RLS患者是否不仅有更高的CVD危险因素患病率，而且他们是否也有后续CVD事件的风险增加。因此，本基金申请要求资助研究RLS，CVD危险因素以及CVD事件之间的关联。