Biomarkers of Dietary Variables Commonly Misreported

膳食变量的生物标志物经常被误报

• 批准号: 7657114
• 负责人: MEGAN A MCCRORY
• 金额: $ 54.76万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7657114
• 关键词: Archives; Beverages; Biological; Biological Markers; Body mass index; Cardiovascular system; Carotenoids; Chronic Disease; Consumption; Data; Diabetes Mellitus; Diet; Dietary Assessment; Dietary Factors; Dietary intake; Disease; Energy Intake; Energy Metabolism; Enrollment; Fatty acid glycerol esters; Food; Frequencies; Fructose; Funding; Future; Goals; Health; Heart Diseases; Hyperphagia; Individual; Intake; Knowledge; Label; Laboratories; Lead; Life; Life Style; Macronutrients Nutrition; Measures; Methodology; Methods; Nature; Nutrient; Obesity; Outcome; Overweight; Participant; Patient Self-Report; Physical activity; Physiological; Plasma; Population; Recruitment Activity; Relative (related person); Reporter; Reporting; Risk; Risk Factors; Sampling; Sampling Studies; Series; Serum; Source; Sucrose; Suggestion; System; Techniques; Testing; Total Sugar; Universities; Vitamin K; Vitamin K 1; Water; Weight; Weight Gain; Woman; Work; aged; base; cancer type; diabetes risk; disorder risk; energy density; fruits and vegetables; improved; men; novel; programs; research study; response; sugar; urinary

Current methods for measuring dietary intake in free-living people typically result in an average under-estimation of energy intake (EI) of 10-50%. Data are suggestive, but not conclusive, that EI underreporting is specific to foods and beverages high in energy density (i.e., high in sugar and/or fat). Our work and that of others has shown that dietary misreporting, that is, underreporting or overreporting, may result in spurious statistical associations of dietary variables with body mass index (BMI) and chronic disease risk factors, which in turn may lead to incorrect conclusions about potential dietary contributors to overeating, obesity, and other health outcomes. Biomarkers that serve as objective, independent measures of dietary variables thought to be commonly and selectively misreported would help to verify which specific dietary factors are misreported by which individuals. In this response to PAR-07-259, Improving Diet and Physical Activity Assessment, our overall hypothesis is that dietary misreporting is specific to certain types of foods and/or nutrients; in particular, foods high in sugar and/or fat are underreported, and fruits and vegetables are overreported. We will recruit n=181 ethnically diverse men and women aged 18-65 y and BMI 18.5-45 kg/m2 primarily from the Healthy Purdue population--a university-based healthy lifestyle program with >9000 participants--but also from other sources. We will test our hypotheses by assessing a combination of novel (urinary sucrose + fructose for foods high in sugar) and established (plasma carotenoids and serum phylloquinone for fruits and vegetables) dietary biomarkers, reported dietary intakes, and their relationships with each other as well as with health outcomes in the total study sample (n=181) compared to the subsample of physiologically plausible EI reporters (target n≥120; where, according to previously-established methodology, an individual’s EI will be regarded as plausible if it is within ±1 SD of total energy expenditure measured by doubly labeled water). We expect the results of this study improve our understanding of the nature of reporting error in dietary assessment methodology, and ultimately help clarify relationships between different components of dietary intake and health outcomes.

目前测量自由生活人群膳食摄入量的方法通常会导致对能量摄入（EI）的平均低估10-50%。数据是提示性的，但不是结论性的，EI低报是高能量密度（即高糖和/或高脂肪）的食品和饮料所特有的。我们和其他人的研究表明，饮食误报，即少报或多报，可能导致饮食变量与体重指数（BMI）和慢性疾病风险因素之间存在虚假的统计关联，这反过来可能导致关于饮食可能导致暴饮暴食、肥胖和其他健康结果的错误结论。作为客观、独立的饮食变量测量的生物标志物被认为是普遍和选择性误报的，将有助于验证哪些特定的饮食因素被哪些个体误报。在对PAR-07-259“改善饮食和身体活动评估”的回应中，我们的总体假设是饮食误报仅限于某些类型的食物和/或营养素；特别是，高糖和/或高脂肪的食物被低估了，水果和蔬菜被高估了。我们将招募n=181名年龄在18-65岁、体重指数18.5-45 kg/m2的不同种族的男性和女性，主要来自健康普渡人群——一个以大学为基础的健康生活方式项目，有bbb9000名参与者——但也来自其他来源。我们将通过评估新的（高糖食物的尿蔗糖+果糖）和已建立的（水果和蔬菜的血浆类胡萝卜素和血清叶绿醌）膳食生物标志物的组合来检验我们的假设，报告的膳食摄入量，以及它们之间的关系以及与健康结果的关系，总研究样本（n=181）与生理上合理的EI报告者的子样本(目标n≥120；其中，根据先前建立的方法，如果一个人的EI在双标签水测量的总能量消耗的±1个标准差范围内，则被认为是可信的)。我们期望这项研究的结果能提高我们对饮食评估方法中报告错误本质的理解，并最终有助于澄清饮食摄入不同组成部分与健康结果之间的关系。