UCD MUTANT MOUSE REGIONAL RESOURCE CENTER: AIDS

都柏林大学突变小鼠区域资源中心：艾滋病

• 批准号: 7961199
• 负责人: STEPHEN WILLIAM BARTHOLD
• 金额: $ 26.68万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7961199
• 关键词: Acquired Immunodeficiency Syndrome; Anatomy; Area; Behavioral; Biology; Biomedical Research; Breeding; Censuses; Clinical; Communicable Diseases; Communities; Computer Retrieval of Information on Scientific Projects Database; Cryopreservation; Diagnostic; Education and Outreach; Educational process of instructing; Embryo; Faculty; Fees; Freezing; Funding; Genotype; Grant; Healthcare; Institution; Knock-out; Laboratory mice; Link; Maintenance; Medicine; Mission; Mus; Mutant Strains Mice; Pathology; Phenotype; Request for Applications; Research; Research Personnel; Resources; Services; Source; Training and Education; Transgenic Organisms; United States National Institutes of Health; Veterinary Medicine; comparative; cost; embryonic stem cell; improved; medical schools; mutant; programs; research and development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Regarding AIDS DESCRIPTION (provided by applicant): This is a resubmission of the first competitive continuing application requesting NIH/NCRR support for the next 5 years of the UC Davis Mutant Mouse Regional Resource Center (UCD-MMRRC). The overall objective of the UCD-MMRRC is to serve as a component of the MMRRC National Program, to accept, maintain, and distribute mutant mouse strains for use in biomedical research. The MMRRC program accepts transgenics, knockouts, and all other kinds of mutant mouse lines at no cost to the donor, and after SPF-rederivation and cryopreservation, distributes breeding stock orgermplasm of genetically. In many cases phenotypically verified mice for a small fee to requesting investigators for non-commercial, academic research purposes only. The UCD-MMRRC currently has a census of >9000 mutant strains maintained as either actively breeding mouse colonies, frozen embryos or germplasm, and/or embryonic stem cell clones. Further, the UCD-MMRRC serves in a coordinated network with 3 other regional MMRRCs as a center of excellence engaged in research and teaching on the biology of the laboratory mouse, providing the scientific community with professional expertise in mutant mouse biology, colony management, conventional and advanced genotyping and phenotyping capabilities, clinical and anatomic pathology services, strain rescue, infectious disease diagnostics and health care, and other areas. In keeping with this mission, this application states 4 interconnected Specific Aims that focus on continuing maintenance of mutant mouse lines in the resource, acceptance of new lines into the resource, research and development projects that eventually will be transferred to the resource to improve its functional efficiency and capabilities, and finally to provide opportunities for outreach and education and training in mouse biology. These Specific Aims are facilitated by closely linked faculty expertise of the UCD Center for Comparative Medicine (CCM), the UCD Mouse Biology Program (UCD-MBP), and the Schools of Medicine and Veterinary Medicine. These relationships allow leveraging of MMRRC support, resulting in expanded opportunities for, and benefit to, the MMRRC National Program and the biomedical and behavioral scientific research community.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 关于艾滋病 描述(由申请人提供)： 这是加州大学戴维斯分校突变小鼠区域资源中心(UCD-MMRRC)重新提交的第一份竞争性持续申请，请求NIH/NCRR在未来5年提供支持。UCD-MMRRC的总体目标是作为MMRRC国家计划的一个组成部分，接受、维护和分发用于生物医学研究的突变小鼠品系。MMRRC计划免费接受转基因、基因敲除和所有其他类型的突变小鼠品系，并在SPF再衍生和超低温保存后，以遗传方式分发种质资源。在许多情况下，表型验证小鼠只需向请求研究人员支付少量费用，仅用于非商业性、学术研究目的。UCD-MMRRC目前拥有9000个突变菌株的普查，这些突变菌株要么是活跃繁殖的小鼠群体，要么是冷冻的胚胎或种质，要么是胚胎干细胞克隆。此外，UCD-MMRRC与其他3个地区MMRRC建立了协调网络，作为从事实验室小鼠生物学研究和教学的卓越中心，为科学界提供突变小鼠生物学、群体管理、常规和高级基因分型和表型鉴定能力、临床和解剖病理学服务、品系救援、传染病诊断和医疗保健等领域的专业专业知识。为了与这一使命保持一致，本申请陈述了4个相互关联的具体目标，重点是继续维护资源中的突变小鼠品系，接受资源中的新品系，研究和开发项目，这些项目最终将转移到资源以提高其功能效率和能力，最后提供推广和小鼠生物学教育和培训的机会。这些具体目标是由UCD比较医学中心(CCM)、UCD小鼠生物学项目(UCD-MBP)以及医学院和兽医学院密切联系的教师专业知识推动的。这些关系允许利用MMRRC的支持，从而为MMRRC国家计划以及生物医学和行为科学研究社区带来更多机会并从中受益。