UCD MUTANT MOUSE REGIONAL RESOURCE CENTER

都柏林大学突变小鼠区域资源中心

• 批准号: 8356894
• 负责人: STEPHEN WILLIAM BARTHOLD
• 金额: $ 118.82万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356894
• 关键词: Anatomy; Area; Behavioral; Biology; Biomedical Research; Breeding; Censuses; Clinical; Communicable Diseases; Communities; Cryopreservation; Diagnostic; Education and Outreach; Educational process of instructing; Embryo; Faculty; Fees; Freezing; Funding; Genotype; Grant; Healthcare; Knock-out; Laboratory mice; Link; Maintenance; Medicine; Mission; Mus; Mutant Strains Mice; National Center for Research Resources; Pathology; Phenotype; Principal Investigator; Request for Applications; Research; Research Infrastructure; Research Personnel; Resources; Services; Source; Training and Education; Transgenic Organisms; United States National Institutes of Health; Veterinary Medicine; comparative; cost; embryonic stem cell; improved; medical schools; mutant; programs; research and development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): This is a resubmission of the first competitive continuing application requesting NIH/NCRR support for the next 5 years of the UC Davis Mutant Mouse Regional Resource Center (UCD-MMRRC). The overall objective of the UCD-MMRRC is to serve as a component of the MMRRC National Program, to accept, maintain, and distribute mutant mouse strains for use in biomedical research. The MMRRC program accepts transgenics, knockouts, and all other kinds of mutant mouse lines at no cost to the donor, and after SPF-rederivation and cryopreservation, distributes breeding stock orgermplasm of genetically. In many cases phenotypically verified mice for a small fee to requesting investigators for non-commercial, academic research purposes only. The UCD-MMRRC currently has a census of >9000 mutant strains maintained as either actively breeding mouse colonies, frozen embryos or germplasm, and/or embryonic stem cell clones. Further, the UCD-MMRRC serves in a coordinated network with 3 other regional MMRRCs as a center of excellence engaged in research and teaching on the biology of the laboratory mouse, providing the scientific community with professional expertise in mutant mouse biology, colony management, conventional and advanced genotyping and phenotyping capabilities, clinical and anatomic pathology services, strain rescue, infectious disease diagnostics and health care, and other areas. In keeping with this mission, this application states 4 interconnected Specific Aims that focus on continuing maintenance of mutant mouse lines in the resource, acceptance of new lines into the resource, research and development projects that eventually will be transferred to the resource to improve its functional efficiency and capabilities, and finally to provide opportunities for outreach and education and training in mouse biology. These Specific Aims are facilitated by closely linked faculty expertise of the UCD Center for Comparative Medicine (CCM), the UCD Mouse Biology Program (UCD-MBP), and the Schools of Medicine and Veterinary Medicine. These relationships allow leveraging of MMRRC support, resulting in expanded opportunities for, and benefit to, the MMRRC National Program and the biomedical and behavioral scientific research community.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 描述（由申请人提供）： 这是加州大学戴维斯分校突变小鼠区域资源中心（UCD-MMRRC）未来5年要求NIH/NCRR支持的第一个竞争性持续申请的重新提交。UCD-MMRRC的总体目标是作为MMRRC国家计划的一部分，接受，维护和分发突变小鼠品系用于生物医学研究。MMRRC项目接受转基因、基因敲除和所有其他类型的突变小鼠品系，对捐赠者来说是免费的，在SPF再衍生和冷冻保存之后，分配遗传学上的育种种群或种质。在许多情况下，为了非商业性的学术研究目的，只需要支付少量费用就可以要求研究人员对小鼠进行表型验证。UCD-MMRRC目前拥有超过9000个突变株的普查，这些突变株作为活跃的繁殖小鼠集落，冷冻胚胎或种质，和/或胚胎干细胞克隆。此外，UCD-MMRRC与其他3个区域MMRRC一起作为卓越中心参与实验室小鼠生物学的研究和教学，为科学界提供突变小鼠生物学，菌落管理，常规和先进的基因分型和表型能力，临床和解剖病理学服务，应变救援，传染病诊断和保健方面的专业知识，和其他领域。为了与这一使命保持一致，本申请陈述了4个相互关联的具体目标，重点是继续维护资源中的突变小鼠品系，接受新品系进入资源，最终将转移到资源的研究和开发项目，以提高其功能效率和能力，并最终为小鼠生物学的推广、教育和培训提供机会。这些具体目标是由UCD比较医学中心（CCM），UCD小鼠生物学计划（UCD-MBP）以及医学和兽医学院的密切联系的教师专业知识促进的。这些关系允许利用MMRRC的支持，从而扩大机会，并受益于MMRRC国家计划和生物医学和行为科学研究界。