UCD MUTANT MOUSE REGIONAL RESOURCE CENTER

都柏林大学突变小鼠区域资源中心

• 批准号: 8356894
• 负责人: STEPHEN WILLIAM BARTHOLD
• 金额: $ 118.82万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356894
• 关键词: Anatomy; Area; Behavioral; Biology; Biomedical Research; Breeding; Censuses; Clinical; Communicable Diseases; Communities; Cryopreservation; Diagnostic; Education and Outreach; Educational process of instructing; Embryo; Faculty; Fees; Freezing; Funding; Genotype; Grant; Healthcare; Knock-out; Laboratory mice; Link; Maintenance; Medicine; Mission; Mus; Mutant Strains Mice; National Center for Research Resources; Pathology; Phenotype; Principal Investigator; Request for Applications; Research; Research Infrastructure; Research Personnel; Resources; Services; Source; Training and Education; Transgenic Organisms; United States National Institutes of Health; Veterinary Medicine; comparative; cost; embryonic stem cell; improved; medical schools; mutant; programs; research and development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): This is a resubmission of the first competitive continuing application requesting NIH/NCRR support for the next 5 years of the UC Davis Mutant Mouse Regional Resource Center (UCD-MMRRC). The overall objective of the UCD-MMRRC is to serve as a component of the MMRRC National Program, to accept, maintain, and distribute mutant mouse strains for use in biomedical research. The MMRRC program accepts transgenics, knockouts, and all other kinds of mutant mouse lines at no cost to the donor, and after SPF-rederivation and cryopreservation, distributes breeding stock orgermplasm of genetically. In many cases phenotypically verified mice for a small fee to requesting investigators for non-commercial, academic research purposes only. The UCD-MMRRC currently has a census of >9000 mutant strains maintained as either actively breeding mouse colonies, frozen embryos or germplasm, and/or embryonic stem cell clones. Further, the UCD-MMRRC serves in a coordinated network with 3 other regional MMRRCs as a center of excellence engaged in research and teaching on the biology of the laboratory mouse, providing the scientific community with professional expertise in mutant mouse biology, colony management, conventional and advanced genotyping and phenotyping capabilities, clinical and anatomic pathology services, strain rescue, infectious disease diagnostics and health care, and other areas. In keeping with this mission, this application states 4 interconnected Specific Aims that focus on continuing maintenance of mutant mouse lines in the resource, acceptance of new lines into the resource, research and development projects that eventually will be transferred to the resource to improve its functional efficiency and capabilities, and finally to provide opportunities for outreach and education and training in mouse biology. These Specific Aims are facilitated by closely linked faculty expertise of the UCD Center for Comparative Medicine (CCM), the UCD Mouse Biology Program (UCD-MBP), and the Schools of Medicine and Veterinary Medicine. These relationships allow leveraging of MMRRC support, resulting in expanded opportunities for, and benefit to, the MMRRC National Program and the biomedical and behavioral scientific research community.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 描述（由申请人提供）： 这是第一个竞争性持续申请的重新提交，请求 NIH/NCRR 对加州大学戴维斯分校突变小鼠区域资源中心 (UCD-MMRRC) 未来 5 年的支持。 UCD-MMRRC 的总体目标是作为 MMRRC 国家计划的组成部分，接受、维持和分发用于生物医学研究的突变小鼠品系。 MMRRC 计划免费接受转基因、基因敲除和所有其他类型的突变小鼠品系，并在 SPF 重新衍生和冷冻保存后，从遗传角度分配种畜或种质。在许多情况下，研究人员只需支付少量费用即可对小鼠进行表型验证，仅用于非商业、学术研究目的。 UCD-MMRRC 目前对超过 9000 个突变株进行了普查，这些突变株要么是活跃繁殖的小鼠群体，要么是冷冻胚胎或种质，和/或胚胎干细胞克隆。此外，UCD-MMRRC 与其他 3 个区域 MMRRC 建立协调网络，作为从事实验室小鼠生物学研究和教学的卓越中心，为科学界提供突变小鼠生物学、群体管理、常规和先进基因分型和表型能力、临床和解剖病理学服务、菌株救援、传染病诊断和医疗保健等方面的专业知识。 地区。为了与这一使命保持一致，该申请提出了 4 个相互关联的具体目标，重点是继续维护资源中的突变小鼠品系、接受新品系进入资源、最终将转移到资源中以提高其功能效率和能力的研究和开发项目，最后为小鼠生物学的外展、教育和培训提供机会。这些具体目标得到了都柏林大学比较医学中心 (CCM)、都柏林大学小鼠生物学项目 (UCD-MBP) 以及医学院和兽医学院密切联系的教师专业知识的推动。这些关系允许利用 MMRRC 的支持，从而为 MMRRC 国家计划以及生物医学和行为科学研究界带来更多机会并从中受益。