Defining Human Cortical Functional Areas Using Resting Functional Connectivity

使用静息功能连接定义人类皮质功能区域

• 批准号: 7588068
• 负责人: Alexander Li Cohen
• 金额: $ 2.79万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7588068
• 关键词: Aging; Area; Brain; Clinical; Collection; Development; Functional Imaging; Functional Magnetic Resonance Imaging; Generations; Human; Image Analysis; Individual; Label; Life; Location; Maps; Measures; Methods; Pattern; Population Study; Research; Rest; Signal Transduction; Study Subject; tool

DESCRIPTION (provided by applicant): The objective of this research is to use intrinsic ongoing fluctuations in human brain activity to delineate cortical functional areas in individuals. Defining functional areas in living humans is currently only possible for a small fraction of areas. As such, the generation of cortex-wide maps of functional areas for individuals would allow for more accurate and functionally meaningful distinctions to be utilized without relying on current stereotactic or functional localizer approaches. The current study will utilize spontaneous fluctuations in the resting state fMRI BOLD signal (rs-fcMRI). rs-fcMRI across expanses of cortex show strong localized differences in patterns of correlation strength. These localized differences will then be analyzed using a set of image analysis tools to explore the plausibility of using rs-fcMRI measures to aid in the definition of widespread functional area boundaries. In addition to providing better areal labeling within individuals, this method would allow us to directly examine the variability of area extent, location, and organization across subjects, which is currently extremely difficult, if not impossible, to do with functional imaging. If the full, or even a partial, collection of functional areas can be delineated and characterized across subjects, the study of anatomical and functional differences between groups, including developmental studies, studies of normal or abnormal aging, or clinical population studies will be greatly facilitated.

描述（由申请人提供）： 本研究的目的是利用人类大脑活动的内在持续波动来描绘个体的皮质功能区。在活体人类中定义功能区域目前只可能用于一小部分区域。因此，为个体生成功能区的皮层范围图将允许在不依赖于当前立体定向或功能定位器方法的情况下利用更准确和功能上有意义的区分。目前的研究将利用静息状态fMRI BOLD信号（rs-fcMRI）的自发波动。跨皮层的扩展的rs-fcMRI在相关强度的模式中显示出强烈的局部差异。然后，这些局部差异将使用一组图像分析工具进行分析，以探索使用rs-fcMRI措施来帮助定义广泛的功能区边界的可行性。除了在个体内提供更好的区域标记外，这种方法还允许我们直接检查受试者之间区域范围，位置和组织的变化，这在功能成像中非常困难，如果不是不可能的话。如果可以在受试者之间描绘和表征全部或部分功能区域的集合，则将极大地促进组之间的解剖学和功能差异的研究，包括发育研究、正常或异常老化的研究或临床人群研究。