Neurological Emergencies Treatment Trials (NETT) Network; U. of Mn. Hub

描述(由申请人提供)：有效研究流行病学、病理生理学和神经紧急情况的潜在创新治疗方法的能力一直很困难，因为许多情况下很少发生。这些事件的罕见往往降低了招募足够数量的患者参加临床试验的能力。目前许多神经急症的治疗方法往往研究不足或不能令人满意。考虑到这些问题，并出于改善神经紧急情况患者紧急护理的真诚愿望，神经紧急情况治疗试验(NETT)网络应运而生。这项建议是为了在明尼苏达大学医学院急诊医学系建立NETT网络枢纽。作为多个城乡、学术和社区ED Spokes的协调中心，该中心将促进和确保成功招募和登记患者参加国家NETT网络提出的临床试验。该中心将促进传播由此产生的相关研究成果，目的是直接影响神经紧急情况患者的护理。这项提案第一年的具体目标是：1.在明尼苏达大学急诊医学系创建Hub基础设施，以促进和进行神经学临床试验，目标是确定对其他毁灭性疾病的有效新疗法。这将包括1)中心领导和行政基础设施的发展；2)与拟议的SPOKS就研究后勤问题达成合作协议；3)为发言研究提供必要的支持系统、政策和程序；4)关于SPOKS的培训模块，涉及研究的原则和实践、研究中的人类主体保护和具体的研究协议。2.让急诊和神经临床医生参与临床研究试验。这包括支持有发言权的急诊医生和神经临床同事之间的合作和沟通，关于最佳临床实践和研究试验设计的教育，以及为患者识别和研究登记开发无缝研究流程。3.让院前服务提供者参与研究工作。这将包括在几个紧急医疗服务系统中积极促进沟通，并就登记业绩提供反馈。4.4.在第2-5年，实施并成功执行NETT网络确定的两项临床试验。

DESCRIPTION (provided by applicant): The ability to effectively study the epidemiology, pathophysiology and potential innovative treatments for neurological emergencies has been difficult, since many occur infrequently. The rarity of these events often lessens the ability to enroll sufficient numbers of patients into clinical trials. The current therapies for many neurologic emergencies are often understudied or unsatisfactory. With these issues in mind, and because of a sincere desire to improve emergency care of patients with neurological emergencies, the Neurological Emergencies Treatment Trials (NETT) network has been proposed. This proposal is for the establishment of a NETT network Hub at the University Of Minnesota School Of Medicine, Department of Emergency Medicine. As the coordinating center for several urban and rural, academic and community ED Spokes, the Hub will promote and ensure the successful recruitment and enrollment of patients into clinical trials proposed by the national NETT Network. The Hub will promote dissemination of the resulting relevant research findings with the goal of directly impacting the care of patients with neurological emergencies. The Specific Aims for Year One of this proposal are to; 1. Create the Hub infrastructure at the University Of Minnesota Department Of Emergency Medicine to promote and conduct neurological clinical trials, with the goal of determining effective new treatments for otherwise devastating pathologies. This will include the development of 1) Hub leadership and administrative infrastructure; 2) collaborative agreements with proposed Spokes regarding research logistics; 3) necessary support systems, policies and procedures for Spoke research; 4) training modules for Spokes related to principles and practice of research, human subjects protection in research and specific research protocols. 2. Engage emergency and neuro- clinicians in clinical research trials. This includes support of collaboration and communication between Spoke emergency physicians and neuroclinical colleagues, education regarding best clinical practices and research trial designs, and development of seamless research processes for patient identification and study enrollment. 3. Engage pre-hospital providers in the research effort. This will include active promotion of communications across several emergency medical service systems and providing feedback on enrollment performance. 4.4. In Years 2-5, implement and successfully execute two clinical trials, as determined by the NETT network.