Neurological Emergencies Treatment Trials (NETT) Network Clinical Site Hubs

神经急症治疗试验 (NETT) 网络临床站点中心

• 批准号: 8868175
• 负责人: Michelle Helen Biros
• 金额: $ 30.13万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-03 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8868175
• 关键词: Acute; Budgets; Catchment Area; Certification; Clinical; Clinical Trials; Communities; Consent; Development; Drug usage; Education; Emergency treatment; Enrollment; Ensure; Evaluation; Fostering; Future; Goals; Hospitals; Informed Consent; Injury; Institution; Institutional Review Boards; Instruction; Learning; Medical; Medical emergency; Minnesota; Mission; Modeling; Neurologic; Neurological emergencies; Neurosciences; Patients; Population; Research; Research Personnel; Resources; Rural; Science; Secure; Site; System; Telemedicine; Time; Training; Universities; clinical research site; meetings; outreach; patient advocacy group; patient population; prototype; treatment trial

Neurolgical Emergencies Treatment Trials ( NETT ) research network was established to develop new therapies for acute neurological illness and injury. By bringing together likeminded and dedicated researchers at several academic institutions across the US, the NETT provides an efficient and effective means to rapidly study and advance the science needed for medical progress. This proposal is for renewal ofthe University of Minnesota NETT Hub . We currently have 9 Spokes , with recent additions increasing our catchment area to cover most population centers in our State. We engage at least 30 clinician investigators at these sites. We partner with state patient advocacy groups and include education and clinical outreach as well as research in our mission. As the coordinating center for several urban and rural, academic and community Spokes, the Minnesota Hub has promoted and provided successful Spoke development, and the recruitment and enrollment of patients into all NETT studies implemented so far, and looks forward to partipcation in future NETT clinical trials. The Minnesota Hub has used the lessons learned from one study to streamline the start up ofthe next. This includes , among others, the development of different models for Hub support of Spokes, a "one number" alert system to deploy an on- call Hub research team, an IRB approved prototype for rapid evaluation and implementation of Exception from Informed Consent ( EFIC) studies, exploration of telemedicine for enrollment and consent of patients at remote sites, creative budgeting to ensure adequate reimbursment for certification and training time for Spoke investigators, and a secure storage cabinent and tracking system for study drugs used out of hospital. The specific aims of this proposal are ; 1) to use lessons learned to efficiently implement additonal ( 4-7 ) trials performed by the NETT 2) to actively develop exisitng and new spokes and investigators in their independent research capacities 3) to serve as a state wide resource for patients and the neuroscience and emergency medical communities

建立了神经系统紧急治疗试验（NETT）研究网络，以开发急性神经系统疾病和损伤的新疗法。通过汇集美国几个学术机构的志同道合和敬业的研究人员，NETT提供了一种高效和有效的手段来快速研究和推进医学进步所需的科学。 本提案是为明尼苏达大学网络技术中心的更新而提出的。我们目前有9个辐条，最近增加了我们的集水区，以覆盖我们州的大多数人口中心。我们在 这些研究中心至少有30名临床研究者。我们与州患者倡导团体合作，并在我们的使命中包括教育和临床推广以及研究。作为几个城市和农村，学术和社区辐条的协调中心，明尼苏达州中心促进并提供了成功的辐条开发，以及迄今为止实施的所有NETT研究的患者招募和入组，并期待着在未来的NETT临床试验中的参与。 明尼苏达枢纽已经使用了从一项研究中吸取的教训，以简化启动下一个。这包括，除其他外，开发不同的模式，用于中心支持辐条，“一个数字”警报系统，以部署一个随叫随到的中心研究团队，IRB批准的原型，用于快速评估和实施知情同意例外（EFIC）研究，探索远程医疗的招募和远程站点患者的同意，创造性的预算，以确保充分的补偿， Spoke研究者的认证和培训时间，以及医院外使用的研究药物的安全储存柜和跟踪系统。 这项建议的具体目标是： 1)利用所吸取的经验教训，有效地实施由NETT进行的额外（4-7）试验 2)积极发展具有独立研究能力的研究人员和新的研究人员 3)为病人、神经科学和急救医学界提供全州范围的资源