Neurological Emergencies Treatment Trials (NETT) Network Clinical Site Hubs

建立了神经紧急治疗试验(NETT)研究网络，以开发急性神经疾病和损伤的新疗法。通过将全美几个学术机构志同道合、敬业的研究人员聚集在一起，NETT为快速研究和推进医学进步所需的科学提供了一种高效和有效的手段。 这项提案是为了更新明尼苏达大学的NETT中心。我们目前有9个Spoke，最近增加了我们的集水区，覆盖了我们州的大多数人口中心。我们在以下位置参与 这些地点至少有30名临床医生调查人员。我们与州患者倡导团体合作，并在我们的使命中包括教育和临床推广以及研究。作为几个城乡、学术和社区Spoke的协调中心，明尼苏达中心已经推动和提供了成功的SPORT开发，以及迄今为止实施的所有NETT研究的患者招募和登记，并期待在未来的NETT临床试验中进行分割。 明尼苏达中心利用从一项研究中吸取的经验教训，简化了下一项研究的启动过程。除其他外，这包括为Spokes的中心支持开发不同的模型，部署待命中心研究团队的“一号”警报系统，IRB批准的用于快速评估和实施知情同意例外(EFIC)研究的原型，探索远程医疗登记和远程站点患者的同意，创造性预算以确保足够的报销 为分支调查人员提供认证和培训时间，以及一个安全的储藏柜和跟踪系统，用于研究医院外使用的药物。 这项建议的具体目标是； 1)利用吸取的经验教训，有效地实施NETT进行的额外(4-7)试验 2)积极发展现有和新的分支机构和调查人员的独立研究能力 3)为患者、神经科学和急救医学界提供全州范围的资源

Neurolgical Emergencies Treatment Trials ( NETT ) research network was established to develop new therapies for acute neurological illness and injury. By bringing together likeminded and dedicated researchers at several academic institutions across the US, the NETT provides an efficient and effective means to rapidly study and advance the science needed for medical progress. This proposal is for renewal ofthe University of Minnesota NETT Hub . We currently have 9 Spokes , with recent additions increasing our catchment area to cover most population centers in our State. We engage at least 30 clinician investigators at these sites. We partner with state patient advocacy groups and include education and clinical outreach as well as research in our mission. As the coordinating center for several urban and rural, academic and community Spokes, the Minnesota Hub has promoted and provided successful Spoke development, and the recruitment and enrollment of patients into all NETT studies implemented so far, and looks forward to partipcation in future NETT clinical trials. The Minnesota Hub has used the lessons learned from one study to streamline the start up ofthe next. This includes , among others, the development of different models for Hub support of Spokes, a "one number" alert system to deploy an on- call Hub research team, an IRB approved prototype for rapid evaluation and implementation of Exception from Informed Consent ( EFIC) studies, exploration of telemedicine for enrollment and consent of patients at remote sites, creative budgeting to ensure adequate reimbursment for certification and training time for Spoke investigators, and a secure storage cabinent and tracking system for study drugs used out of hospital. The specific aims of this proposal are ; 1) to use lessons learned to efficiently implement additonal ( 4-7 ) trials performed by the NETT 2) to actively develop exisitng and new spokes and investigators in their independent research capacities 3) to serve as a state wide resource for patients and the neuroscience and emergency medical communities