Assessing Impulsivity in High Alcohol Preferring Mice

评估高酒精偏好小鼠的冲动性

基本信息

批准号：
7876972
负责人：
Brandon Oberlin
金额：
$ 1.71万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-16 至 2010-03-01
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7876972
关键词：
Alcohol consumption Alcohol dependence Alcoholism Alcohols Animal Model Animals Behavior Behavior Therapy Behavioral Characteristics Cigarette Smoker Cocaine Decision Making Deltastab Disease Drug usage Early treatment Environmental Monitoring Ethanol Exposure to Fellowship Genetic Genetic Markers Genetic screening method Goals Human Impulsivity Individual Knowledge Lead Link Literature Measures Minority Modeling Mus Names Opiates Pharmacotherapy Phenotype Predisposing Factor Rattus Recording of previous events Research Rewards Saccharin Self Administration Sorting - Cell Movement Testing addiction alcohol effect alcohol exposure alcohol preferring mice alcohol reinforcement alcohol reward alcohol seeking behavior base design discount discounting drinking drug addict drug of abuse high reward high risk human data insight neurochemistry novel therapeutics preference problem drinker reinforcer relating to nervous system

项目摘要

DESCRIPTION (provided by applicant): The long-range goal of this proposal is to better understand impulsive choice as it relates to alcoholism. Impulsivity may well contribute to the behavior of alcoholism: both human and animal literature shows that impulsivity predates alcoholism. We will use the delay discounting task (an established model of impulsivity) to assess impulsivity in an animal model of alcoholism, the High Alcohol Preferring (HAP) mice. Our general hypothesis is that the HAP mice will show higher impulsivity with saccharin rewards than the Low Alcohol Preferring mice. Intolerance to delay of reward is characteristic of drug addicts, alcoholics, and compulsive gamblers. Additionally, we aim to assess HAP mice that have been exposed to ethanol to see if ethanol exposure itself contributes to impulsive choice. If we can demonstrate that the HAP mice, which have been selected on the basis of alcohol preference, are more impulsive, then we can show that impulsivity is coselected with alcohol preference, and we will have an animal model of impulsivity. We will also seek to determine if ethanol exposure itself exacerbates impulsivity. An animal model of impulsivity will allow the field to move forward by discovering neurochemical and anatomical substrates of impulsivity.

描述（由申请人提供）：该提案的远程目标是更好地理解与酒精中毒有关的冲动选择。冲动可能会有助于酒精中毒的行为：人类和动物文学都表明冲动性早于酒精中毒。我们将使用延迟折现任务（既定的冲动模型）来评估酒精中毒动物模型，即高酒精偏爱（HAP）小鼠。我们的总体假设是，与低酒精偏爱小鼠相比，HAP小鼠对糖精的冲动表现出更高的冲动性。延迟奖励的不宽容是吸毒者，酗酒者和强迫性赌徒的特征。此外，我们旨在评估暴露于乙醇的HAP小鼠，以了解乙醇暴露本身是否有助于冲动选择。如果我们可以证明，基于酒精偏好选择的HAP小鼠更加冲动，那么我们可以证明冲动性与酒精偏爱同时同时使用，我们将具有冲动性动物模型。我们还将寻求确定乙醇暴露本身是否加剧了冲动性。冲动性动物模型将使该领域通过发现冲动性的神经化学和解剖学基质来向前发展。