EFFECT OF DOXYCYCLINE ON SPUTUM BIOMARKERS OF INFLAMMATION AND LUNG EPITHELIA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 强力霉素，一种用于治疗细菌感染的治疗药物，已被证明可以减少炎症。本研究的目的是评估多西环素的安全性和有效性，并确定多西环素是否可以减少囊性纤维化患者的炎症。选定的CF患者将接受多西环素研究药物治疗28天。在整个28天期间，将通过抽血、肺功能检查、体格检查和电话随访对受试者进行密切监测。此外，患者将在多西环素给药后随访2周。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Doxycycline, a therapeutic drug used to treat bacterial infections and has been shown to decrease inflammation. The purpose of this study is to assess the safety and effectiveness of doxycycline and to determine if doxyxyxline can decrease inflammation in cystic fibrosis patients. Selected CF patients will receive doxycycline study drug treatmetn for a period of 28 days. Subjects will be closely monitored through blood draws, pulmonary function tests, physical exams, and follow up phone calls throughout the 28-day period. In addtiona, patients will be followed for 2 weeks following the doxycycline administration.