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EFFECTS OF PIOLITAZONE ON SPUTUM BIOMARKERS OF INFLAMMATION AND LUNG EPITHELI

EFFECTS OF PIOLITAZONE ON SPUTUM BIOMARKERS OF INFLAMMATION AND LUNG EPITHELI
吡奥利他酮对炎症和肺上皮痰生物标志物的影响
批准号：
7982137
负责人：
PAUL BERINGER
金额：
$3.25万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
项目状态：
已结题
起止时间：
2008-12-01 至 2009-11-30
来源：
https://reporter.nih.gov/project-details/7982137
关键词：
2,4-thiazolidinedioneBiological MarkersClinical ResearchComputer Retrieval of Information on Scientific Projects DatabaseDoseFundingGelatinase BGrantInstitutionLung InflammationModelingPhase II Clinical TrialsPioglitazoneResearchResearch PersonnelResourcesSourceSputumThiazolidinedionesUnited States National Institutes of Healthcystic fibrosis patients

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英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study we intend to assess the effect of the PPARy-activating thiazolidinedione pioglitazone on sputum MMP-9 levels in patients with Cystic Fibrosis. A PK/PD model will be developed to determine the optimal dose for phase II studies
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