EFFECTS OF PIOLITAZONE ON SPUTUM BIOMARKERS OF INFLAMMATION AND LUNG EPITHELI

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在这项研究中，我们打算评估PPAR γ活化噻唑烷二酮吡格列酮对囊性纤维化患者痰液MMP-9水平的影响。将开发PK/PD模型，以确定II期研究的最佳剂量

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study we intend to assess the effect of the PPARy-activating thiazolidinedione pioglitazone on sputum MMP-9 levels in patients with Cystic Fibrosis. A PK/PD model will be developed to determine the optimal dose for phase II studies