P-GLYCOPROTEIN AND RENAL CLEARANCE OF ANTIBIOTICS IN CF

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。本研究的目的是确定肾组织P-gp对双氯西林清除的相对贡献。比较两组中双氯西林单独及联合丙磺舒(有机阴离子转运抑制剂)和环孢菌素(P-gp抑制剂)的肾清除情况。这项研究的结果可能为CF患者某些化合物的肾脏清除改变提供一个潜在的机制解释。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine the relative contribution of renal P-gp to the clearance of dicloxacillin in patients with CF and healthy controls subjects. The renal clearance of dicloxacillin alone and in combination with probenecid (organic anion transport inhibitor), and cyclosporine (an inhibitor of P-gp) will be compared in both groups. The results of this study may provide a potential mechanistic explanation for the altered renal clearance of certain compounds in patients with CF.