DEVELOPMENT AND TESTING OF A 1 YEAR MAINTENANCE INTERVENTION TO REDUCE OBESIT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 本研究的总体目的是设计和测试一个为期8个月的维持计划的效果，以延长16周的强化营养和运动干预，以降低“高危”超重少数民族青少年肥胖和2型糖尿病的风险。这项名为佐野LA（洛杉矶的力量和营养结果）的高度创新的16周干预研究目前由NIH资助（PI：Michael Goran博士）。我们建议对本研究进行补充，将干预延长至1年。现有的16周干预和拟议的维持计划将遵循改良的膳食碳水化合物方法（即减少糖和苏打水，增加纤维和全谷物摄入量）以及强度训练方案，我们之前在试点研究中已经证明，它可以减少少数民族青年的肥胖症并改善胰岛素和葡萄糖动力学。受试者将在最初的16岁开始后1年进入GCRC，周干预测试。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall aim of this study is to design and test the effects of an 8-month maintenance program to extend an intensiove 16-week nutrition and exercise interventio to reduce risk of obesity and type 2 diabetes in 'high-risk' overweight minority adolescents. The highly innovative 16-week intervention study, called SANO LA (Strength and Nutrition Outcomes in Los Angeles) is currently funded by the NIH (PI: Dr Michael Goran). We are proposing a supplement to this study to extend the intervention to 1 year. The Existing 16-week intervention and proposed maintenance program will follow the modified dietary carbohydrate approach (i.e. reduce sugar & soda, increased fiber & whole grain intake) as well as a strengh training protocol, which we have previously shown in pilot studies to reduce adioposity and improve insulin and glucose dynamics in minority youth.Subjects will come to the GCRC at 1 year from the start of the original 16-week intervention for testing.