P & P OF FRUCTOSE FOLLOWING SOFT DRINK CONSUMPTION: SUCROSE VS HIGH FRUCTOSE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 在过去的几十年里，果糖的消费量急剧上升。 自1967年引入美国以来，高果糖玉米糖浆（HFCS）已取代蔗糖成为制造食品和饮料的主要甜味剂，并导致我们饮食中果糖增加约30%。 大量研究表明，过量的果糖摄入会导致各种有害的代谢效应，这表明果糖可能是目前肥胖、高血压、代谢综合征和糖尿病流行的部分原因。 研究结果存在一些差异，这可能与个体对果糖的不同反应有关。 缺乏研究调查膳食果糖的来源，蔗糖与高果糖玉米糖浆，对身体的影响不同，影响各种健康问题的发展。 我们建议进行一项初步研究，以探讨果糖在广泛人群中的药代动力学和药效学。 我们研究的目的是通过测量反应表型（如血清尿酸、乳酸和甘油三酯水平），比较膳食果糖的两种主要来源（蔗糖与HFCS）对果糖生物利用度和急性代谢变化的影响。 这项研究将促进我们对果糖的药代动力学和药效学差异的理解，这两种主要的膳食甜味剂是蔗糖和高果糖玉米。 这些发现将使我们能够确定果糖和决定其水平的因素是否可以成为治疗和预防这些流行性健康问题的潜在目标。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Fructose consumption has risen sharply during the past several decades. Since its introduction to the United States in 1967, high fructose corn syrup-HFCS has overtaken sucrose as the main sweetener in manufactured foods and beverages, and is responsible for the approximately 30% increase in fructose in our diet. Numerous studies have shown that excessive fructose consumption can cause a variety of harmful metabolic effects, suggesting that fructose may partially be responsible for the current epidemic in obesity, hypertension, metabolic syndrome, and diabetes. There has been some variability in the findings, which could be related to varying responses to fructose among individuals. There is a lack of studies investigating if the source of dietary fructose, sucrose versus high fructose corn syrup, impacts the body differently, influencing the development of various health problems. We propose to conduct a preliminary study to investigate the pharmacokinetics and pharmacodynamics of fructose in a broad population. The goal of our research is to compare the impact of the two main sources of dietary fructose, sucrose versus HFCS, on fructose bioavailability and acute metabolic changes by measuring response phenotypes, such as serum uric acid, lactate, and triglyceride levels. This study will advance our understanding of the differences in the pharmacokinetics and pharmacodynamics of fructose from two main dietary sweeteners: sucrose versus high fructose corn. These findings will allow us to determine if fructose and factors determining its levels can be potential targets for the therapy and prevention of these epidemic health problems.