PAIN FREE 2

无痛2

• 批准号: 7950741
• 负责人: Linda T Le
• 金额: $ 0.12万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950741
• 关键词: Absence of pain sensation; Adverse effects; Affect; Analgesics; Arthralgia; Catheters; Clinical Research; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Degenerative polyarthritis; Funding; Grant; Hip region structure; Infusion procedures; Institution; Joints; Knee; Local Anesthetics; Masks; Normal saline; Operative Surgical Procedures; Pain; Pain-Free; Patients; Peripheral Nerves; Placebo Control; Postoperative Period; Randomized; Readiness; Rehabilitation therapy; Research; Research Personnel; Resources; Site; Source; Techniques; Time; United States National Institutes of Health; Upper arm; functional disability; functional outcomes; knee replacement arthroplasty; meetings; nerve supply; perineural; primary outcome; secondary outcome

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Following knee and hip replacement, ambulation is often limited by joint pain, greatly decreasing functional mobility, rehabilitation quality, and possibly the ultimate functional outcome. Perineural infusion is a relatively new analgesic technique that involves the percutaneous insertion of a catheter directly adjacent to the peripheral nerves that supply the affected joint. Local anesthetic is then infused via the catheter to provide potent, site-specific analgesia free of significant side effects. The ultimate objective of the proposed research is to determine if perineural local anesthetic infusion in the immediate postoperative period has both short- and long-term benefits following knee replacement surgery for osteoarthritis. The research plan consists of a multicenter, randomized, triple-masked patients, investigators, statisticians, placebo-controlled, parallel-arm clinical investigation. Patients will randomly receive either perineural local anesthetic or normal saline for 4 days following surgery. The primary outcome is the time until three specific, predefined readiness-for-discharge criteria are met following surgery. Secondary outcomes include the relationship between analgesic technique administered in the immediate postoperative period and subsequent pain, stiffness and functional disability.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 膝关节和髋关节置换术后，步行通常会受到关节疼痛的限制，从而大大降低功能活动能力、康复质量，甚至可能影响最终的功能结果。 神经周围输注是一种相对较新的镇痛技术，涉及将导管经皮插入直接邻近供应受影响关节的周围神经。 然后通过导管注入局部麻醉剂，以提供有效的、特定部位的镇痛，且不会产生明显的副作用。 本研究的最终目的是确定术后立即进行神经周围局部麻醉剂输注是否对骨关节炎膝关节置换手术具有短期和长期益处。 该研究计划包括多中心、随机、三重屏蔽患者、研究人员、统计学家、安慰剂对照、平行组临床研究。 手术后 4 天，患者将随机接受神经周围局部麻醉剂或生理盐水。 主要结果是手术后达到三个特定的、预先确定的出院准备标准的时间。次要结果包括术后立即使用的镇痛技术与随后的疼痛、僵硬和功能障碍之间的关系。