PAIN FREE2

无痛2

• 批准号: 7717133
• 负责人: Linda T Le
• 金额: $ 0.98万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717133
• 关键词: Absence of pain sensation; Adverse effects; Affect; Analgesics; Arthralgia; Catheters; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Degenerative polyarthritis; Funding; Grant; Hip region structure; Infusion procedures; Institution; Joints; Knee; Local Anesthetics; Masks; Normal saline; Operative Surgical Procedures; Outcome; Pain; Patients; Peripheral Nerves; Placebo Control; Postoperative Period; Randomized; Readiness; Rehabilitation therapy; Research; Research Personnel; Resources; Site; Source; Techniques; Time; United States National Institutes of Health; Upper arm; day; functional disability; functional outcomes; knee replacement arthroplasty; nerve supply; perineural

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Following knee and hip replacement, ambulation is often limited by joint pain, greatly decreasing functional mobility, rehabilitation quality, and possibly the ultimate functional outcome. Perineural infusion is a relatively new analgesic technique that involves the percutaneous insertion of a catheter directly adjacent to the peripheral nerves that supply the affected joint. Local anesthetic is then infused via the catheter to provide potent, site-specific analgesia free of significant side effects. The ultimate objective of the proposed research is to determine if perineural local anesthetic infusion in the immediate postoperative period has both short- and long-term benefits following knee replacement surgery for osteoarthritis. The research plan consists of a multicenter, randomized, triple-masked patients, investigators, statisticians, placebo-controlled, parallel-arm clinical investigation. Patients will randomly receive either perineural local anesthetic or normal saline for 4 days following surgery. The primary outcome is the time until three specific, predefined readiness-for-discharge criteria are met following surgery. Secondary outcomes include the relationship between analgesic technique administered in the immediate postoperative period and subsequent pain, stiffness and functional disability.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 膝关节和髋关节置换术后，截肢通常受到关节疼痛的限制，大大降低了功能活动度，康复质量，并可能影响最终的功能结局。 神经周围灌注是一种相对较新的镇痛技术，其涉及直接邻近供应受影响关节的周围神经经皮插入导管。 然后通过导管输注局部麻醉剂，以提供有效的、无显著副作用的部位特异性镇痛。 本研究的最终目的是确定在骨关节炎膝关节置换术后，术后即刻神经周围局部麻醉剂输注是否具有短期和长期益处。 研究计划包括一项多中心、随机、三盲患者、研究者、统计学家、安慰剂对照、平行组临床研究。 患者将在手术后随机接受神经周围局部麻醉或生理盐水4天。 主要结局是手术后达到三个特定的预定义出院准备标准的时间。次要结局包括术后即刻给予的镇痛技术与随后的疼痛、僵硬和功能障碍之间的关系。