McDermott Vivarium Renovation to Provide Advanced Animal Imaging

描述(由申请人提供)：本提案的目标是最大限度地利用德克萨斯大学圣安东尼奥健康科学中心(UTHSCSA)研究成像中心(RIC)新创建的动物成像研究综合设施(CFAIR)。这将通过将McDermott临床科学大楼的间隔室空间翻新为灵活使用的配置来实现，以使各种研究物种能够访问CFAIR资源。CFAIR的联合资金来自：NIH/NCRR共享仪器拨款计划(240万美元)；国防高级研究计划局(DARPA；410万美元)；德克萨斯州州长办公室新兴技术基金(ETF)(410万美元)；德克萨斯大学系统研究部副校长的新兴技术匹配基金(ETMF)(200万美元)。正在进行的基础设施资金来源包括NIH/NCRR(CTSA奖)、DARPA、国会授权的研究指令(Cmrd)和德克萨斯州拨款。CFAIR仪器包括：1)内径90厘米，3-特斯拉-西门子TIM Trio MRI/MRS；2)内径25厘米的Concorde Focus 220 Primate PET摄像机；3)内径8 cm的Concorde R5啮齿动物PET摄像机；4)内径30 cm的7-Tesla Bruker Biospec MRI/MRS；5)16 cm内径11.7-Tesla Bruker Biospec MRI/MRS扫描仪；6)16厘米直径7-特斯拉Bruker Pharmascan MRI/MRS这一系列仪器可以为广泛的研究物种提供最先进的结构和功能成像，包括：小鼠、大鼠、猫、兔子、狗、猪、绒猴、猕猴、狒狒，所有这些都正在或即将被UTHSCSA调查人员使用。灵活的使用配置将允许使用任何和所有这些物种的调查人员获得先进的成像方法。

DESCRIPTION (provided by applicant): The goal of this proposal is to maximize investigator utilization of a newly created Comprehensive Facility for Animal Imaging Research (CFAIR) of the Research Imaging Center (RIC) at the University of Texas Health Science Center at San Antonio (UTHSCSA). This will be accomplished by renovating vivarium space in the McDermott Clinical Sciences Building into a flexible-use configuration, to give a wide range of investigational species access to CFAIR resources. CFAIR was jointly funded by: the NIH/NCRR Shared Instrumentation Grant program ($2.4 million); the Defense Advanced Research Projects Agency (DARPA; $4.1 million); the Emerging Technologies Fund (ETF) of the Office of the Governor of Texas ($4.1 million); the Emerging Technologies Matching Fund (ETMF) of the Vice Chancellor for Research of the University of Texas System ($2.0 million). Ongoing infrastructure funding sources include NIH/NCRR (CTSA Award), DARPA, Congressionally Mandated Research Directive (CMRD) and Texas State appropriations. CFAIR instrumentation includes: 1) 90-cm-bore, 3-Tesla Siemens TIM TRIO MRI/MRS; 2) 25-cm-bore Concorde Focus 220 Primate PET camera; 3) a 8-cm-bore Concorde R5 Rodent PET camera; 4) 30-cm-bore 7-Tesla Bruker Biospec MRI/MRS; 5) 16-cm-bore 11.7-Tesla Bruker Biospec MRI/MRS scanner; 6) 16-cm-bore 7- Tesla Bruker Pharmascan MRI/MRS. This array of instruments can provide state-of-the-art structural and functional imaging for a wide range of investigational species, including: mice, rats, cats, rabbits, dogs, pigs, marmosets, macaques, baboons, all of which are in current or pending use by UTHSCSA investigators. Flexible-use configuration will allow access to advanced imaging methods to investigators using any and all of these species.