EQUIPMENT FOR THE BIO5 ANIMAL FACILITY

BIO5 动物设施的设备

• 批准号: 7628312
• 负责人: SUSAN E WILSON-SANDERS
• 金额: $ 50万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7628312
• 关键词: American; Animal Experimentation; Animal Housing; Animals; Area; Arizona; Biomedical Research; Biotechnology; Breeding; Communicable Diseases; Core Facility; Environment; Equipment; Exclusion; Faculty; Funding; Generations; Genetically Engineered Mouse; Goals; Healthy People 2010; Housing; Human Resources; Institutes; Life; Longevity; Maintenance; Medical Research; Mus; Pathologic Processes; Phase; Physiological; Play; Productivity; Quality of life; Recruitment Activity; Reproduction; Research; Research Personnel; Role; Science; System; Techniques; Universities; animal facility; cost; disorder prevention; falls; improved; instrumentation; mouse model; programs; therapy development

DESCRIPTION (provided by applicant): The University of Arizona's (UA) research programs focus on many of the Healthy People 2010 goals including increasing the life span and improving the quality of life of Arizonans and Americans through disease prevention, understanding of basic physiological and pathological processes, discovery of new treatments, and development of life-saving techniques and instrumentation. Animal use plays a vital role in many areas of research, and increased use of animals has coincided with the expansion of biomedical research programs and completion of buildings, which are housing new faculty recruits. Two of the new buildings, The Keating BIO5 Institute for Biomedical Science and Biotechnology and the Medical Research Building (MRB), are to house biomedical researchers who will utilize animals. The two buildings will share a vivarium, which is being completed in the first phase of BIO5 construction (opening Fall 2008). The BIO5 animal facility will be primarily dedicated to the generation and maintenance of genetically engineered mice (40,000 mouse capacity) and will be operated to maximize mouse reproduction, while also optimizing the exclusion of infectious disease. The focus of this request is to assist in the purchase of ventilated housing systems (IVC) for mice, which will be housed in the BIO5 Animal Facility. The equipment will be utilized for PHS-funded research and for the Genetically Engineered Mouse Modeling Core Facility (GEMM Core), which will generate mice for many different animal users. The use of IVC has many benefits. These include improved environment for animals and personnel, increased productivity of breeding animals and research, reduced costs of research, and the ability to maximize animal housing space. The purchase of the IVC will promote the well-bing of both mice and personnel and provide reduced costs for research.

描述（由申请人提供）：亚利桑那大学（UA）研究计划的重点是许多健康人​​2010年的目标，包括通过预防疾病来提高寿命和改善亚利桑那州和美国人的生活质量，了解基本的生理和病理学过程，对新治疗的发现以及生命挽救技术和仪器的发展。动物使用在许多研究领域都起着至关重要的作用，而动物的使用增加与生物医学研究计划的扩展和建筑物的完成相吻合，这些建筑物正在为新的教职员工提供。两座新建筑，基廷Bio5生物医学科学与生物技术研究所和医学研究大楼（MRB），是为了容纳将利用动物的生物医学研究人员。这两座建筑物将共享一个Vivarium，该建筑将在Bio5建设的第一阶段完成（2008年秋季开放）。 Bio5动物设施将主要致力于生成和维持基因工程小鼠（40,000小鼠容量），并将运营以最大程度地提高小鼠繁殖，同时还优化了传染病的排除。该请求的重点是为小鼠购买通风的住房系统（IVC），该系统将安置在Bio5动物设施中。该设备将用于PHS资助的研究以及基因工程的鼠标建模核心设施（GEMM Core），该设备将为许多不同的动物使用者生成小鼠。使用IVC有很多好处。这些包括改善动物和人员的环境，提高繁殖动物的生产力和研究，研究成本降低以及最大化动物住房空间的能力。购买IVC将促进小鼠和人员的井井有条，并提供降低的研究成本。