Noninvasive Estimation of Temperature Change Using Pulse-Echo Ultrasound

使用脉冲回波超声波无创估计温度变化

• 批准号: 7788289
• 负责人: Emad S. Ebbini
• 金额: $ 20.88万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7788289
• 关键词: Address; Adoption; Area; Attention; Breathing; Cardiac; Clinic; Clinical; Collection; Complex; Complication; Data; Data Collection; Devices; Diagnostic; Disease; Equipment; Feedback; Focused Ultrasound Therapy; Frequencies; Goals; Heating; Heterogeneity; High Performance Computing; Image; Induced Hyperthermia; Lead; Lesion; Linear Models; Magnetic Resonance Imaging; Masks; Measurement; Mechanical Stress; Methods; Modality; Modeling; Monitor; Morphologic artifacts; Motion; Physiologic pulse; Procedures; Protocols documentation; Publications; Radiation; Radiofrequency Interstitial Ablation; Research; Resolution; Sampling; Scanning; Solutions; Source; Speed; System; Techniques; Technology; Temperature; Testing; Therapeutic; Time; Tissues; Ultrasonography; base; computerized data processing; cost; data acquisition; design; focus ultra; imaging modality; in vivo; innovation; minimally invasive; novel strategies; public health relevance; response; sound; stem; tumor

DESCRIPTION (provided by applicant): The broad, long-term objective of the proposed research is to develop an integrated system for monitoring and guidance of noninvasive and minimally-invasive thermotherapy devices. We consider the use of pulsed high intensity focused ultrasound (pHIFU) in single-shot mode and raster scanned mode to form volumetric lesions. Noninvasive estimation of tissue temperature in response to the application of therapeutic and sub-therapeutic pHIFU shots is a key to the wide spread acceptance of these devices in the clinic. Pulse-echo ultrasound has been shown to be suitable, in principle, as an image guidance modality with temperature imaging capability. However, noninvasive temperature imaging using pulse-echo ultrasound still suffers from limitations that hindered its adoption in clinical systems. This application addresses these limitations by proposing to develop an integrated imaging system with a variety of imaging modes designed to capture all the spatial and temporal dynamics of tissue deformations, whether native (e.g. due to breathing and cardiac cycle) or source induced. For a pHIFU source with single shots heating mm-size volumes, the mechanical stresses on the tissue due to radiation force effects may require M-mode imaging with high pulse repetition frequency (PRF) to capture the full dynamics of tissue deformation in response to therapeutic and subtherapeutic pulses. In raster-scan mode with relatively large heterogeneous heating field may require a number of A-lines to be acquired at high PRF to capture transient 2D tissue deformations in response to the pulsed source. For both of these modes, we propose new data acquisition protocols mixing full frame 2D RF data collection with M-mode for single-shot pHIFU and M2D-mode for raster-scan volumetric heating mode. By M2D-mode imaging we mean the collection of limited number of neighboring A-lines at the highest possible PRF. This will allow for simultaneous capture of tissue deformations with simultaneously high resolution in space and time to capture the dynamics of the complex temperature field. If successful, this research will lead to a robust real-time temperature imaging using diagnostic pulse-echo ultrasound. This will have significant impact on the clinical acceptance of pHIFU as a cost-effective and reliable modality for delivering thermal therapy to tumors and other tissue abnormalities. PUBLIC HEALTH RELEVANCE: Robust temperature imaging is considered an "enabling technology" for minimally-invasive and noninvasive thermal therapy. Diagnostic pulse-echo ultrasound has the potential for imaging temperature changes in response to heating devices, but suffers from significant limitations that hindered its clinical acceptance. The proposed research addresses these limitations from the system and signal processing design perspectives. If successful, robust real-time temperature estimation for monitoring and guidance of thermal therapy will be developed and be ready for in vivo testing.

描述（由申请人提供）：拟议研究的广泛、长期目标是开发一种用于监测和指导无创和微创热疗设备的集成系统。我们考虑在单次模式和光栅扫描模式下使用脉冲高强度聚焦超声（pHIFU）来形成体积病变。针对治疗性和亚治疗性 PHIFU 注射的应用而对组织温度进行无创估计是这些设备在临床上广泛接受的关键。脉冲回波超声已被证明原则上适合作为具有温度成像功能的图像引导方式。然而，使用脉冲回波超声的无创温度成像仍然存在局限性，阻碍了其在临床系统中的采用。该申请通过建议开发一种具有多种成像模式的集成成像系统来解决这些限制，该系统旨在捕获组织变形的所有空间和时间动态，无论是自然的（例如由于呼吸和心动周期）还是源引起的。对于单次加热毫米尺寸体积的 PHIFU 源，由于辐射力效应而对组织产生的机械应力可能需要具有高脉冲重复频率 (PRF) 的 M 模式成像，以捕获响应治疗和亚治疗脉冲的组织变形的完整动态。在具有相对较大异质加热场的光栅扫描模式下，可能需要在高 PRF 下采集许多 A 线，以捕获响应脉冲源的瞬态 2D 组织变形。对于这两种模式，我们提出了新的数据采集协议，将全帧 2D RF 数据采集与单次 pHIFU 的 M 模式和光栅扫描体积加热模式的 M2D 模式混合在一起。 M2D 模式成像是指以尽可能高的 PRF 收集有限数量的相邻 A 线。这将允许同时捕获组织变形，同时在空间和时间上具有高分辨率，以捕获复杂温度场的动态。如果成功，这项研究将使用诊断脉冲回波超声实现强大的实时温度成像。这将对 PHIFU 作为一种经济高效且可靠的肿瘤和其他组织异常热疗方式的临床接受度产生重大影响。 公共健康相关性：强大的温度成像被认为是微创和无创热疗的“使能技术”。诊断脉冲回波超声具有对加热设备响应的温度变化进行成像的潜力，但存在严重的局限性，阻碍了其临床接受。拟议的研究从系统和信号处理设计的角度解决了这些限制。如果成功，将开发用于监测和指导热疗的强大实时温度估计，并为体内测试做好准备。