Sociodemographic, Biosocial and Behavioral Mechanisms Linked to Earlier Oral Agin

描述（由申请人提供）：该项目的目的是开发一个生物心理社会模型，解释社会人口，生物社会，行为因素如何相互作用，导致晚年的口腔健康差异。在这个项目中检查的口腔老化指标包括牙齿数量、蛀牙、牙周病和口腔症状，如口干和咀嚼食物困难。我们将研究所提出的机制对口腔老化的影响，包括种族/民族，社会经济地位，健康行为，医疗保健的使用和可用性，慢性健康状况，心理和认知特征，以及生物风险因素。我们将专门研究口腔健康和各种生物心理社会因素之间的关系的年龄模式，以了解早期衰老的证据，表现为在特定年龄的口腔健康问题在人口的一些亚群，如穷人和一些种族和少数民族群体的成员。我们特别感兴趣的是研究一些生物风险因素与口腔健康之间的联系，包括炎症，免疫和代谢系统过程以及骨密度的指标。该项目将利用1999-2006年和1988-1994年的全国健康和营养检查调查（NHANES）进行死亡率相关分析和CMV分析。NHANES-死亡率相关数据集将使我们能够根据口腔健康指标制定健康的预期寿命，例如无牙周病的寿命和有天然牙齿的寿命。一套丰富的检查牙科措施和潜在的机制，包括在NHANES测量的生物标志物提供了一个无与伦比的机会，系统和全面地研究机制如何相互作用，以产生口腔健康，以及我们的人口中的一些群体如何获得较差的口腔健康结果，这可能是早期衰老的指标。 公共卫生相关性：重要的是要了解人口，社会经济，心理，医学和生物学因素如何相互作用，以产生美国人口亚群之间的口腔健康差异。深入了解这些影响因素及其相互作用，不仅有助于缩小不同人群口腔健康状况的差异，而且有助于提供改善口腔健康状况的策略。此外，鉴于口腔健康状况可能与衰老相关的主要慢性疾病有关，包括心血管疾病，糖尿病和骨质疏松症，因此了解口腔保健和其他医疗保健的相互作用机制以改善整体健康状况非常重要。

DESCRIPTION (provided by applicant): The aim of this project is to develop a biopsychosocial model that explains how sociodemographic, biosocial, behavioral factors interact with one another to lead to differential oral health in later life. Oral aging indicators examined in this project include tooth count, tooth decay, periodontal disease, and oral symptoms such as dry mouth and difficulty chewing foods. We will examine the effect on oral aging of the proposed mechanisms including race/ethnicity, socioeconomic status, health behaviors, health care use and availability, chronic health conditions, psychological and cognitive characteristics, and biological risk factors. We will specifically examine the age patterns of the relationship between oral health and various biopsychosocial factors in order to understand the evidence of earlier aging manifested by the higher presence at a given age of oral health problems in some subgroups of the population such as the poor and members of some racial and ethnic minority groups. We are particularly interested in looking at the link between some biological risk factors and oral health including indicators of inflammatory, immune and metabolic system processes, and bone density. This project will use the National Health and Nutrition Examination Survey (NHANES) 1999-2006, and 1988-1994 for mortality-linked analyses and analyses with CMV. NHANES-mortality linked data set will allow us to develop healthy life expectancy based on oral health indicators such as years of life without periodontal disease and years of life with natural teeth. A rich set of examined dental measures and potential mechanisms including biomarkers measured in NHANES provides an unparalleled opportunity to systematically and comprehensively study how mechanisms interact with one another to produce oral health and how some groups of our population get to poorer oral health outcomes, which can be an indicator of earlier aging. PUBLIC HEALTH RELEVANCE: It is important to understand how demographic, socioeconomic, psychological, medical and biological factors interact to produce oral health disparities across population subgroups in the United States. Better understanding the mediating factors and their interactions would not only help reduce the disparities of oral health among different populations, but it would also help provide strategies to improve oral health status. In addition, given that oral health status can be related to major chronic conditions related to aging, including cardiovascular disease, diabetes and osteoporosis, it is important to understand interacting mechanisms by which oral health care and other medical care can be coordinated to improve overall health status.