Sociodemographic, Biosocial and Behavioral Mechanisms Linked to Earlier Oral Agin

与早期口腔衰老相关的社会人口学、生物社会和行为机制

• 批准号: 7739293
• 负责人: Jung Ki Kim
• 金额: $ 22.22万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-19 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7739293
• 关键词: Affect; Age; Age of Onset; Aging; American; Attention; Awareness; Behavioral; Behavioral Mechanisms; Biologic Characteristic; Biological; Biological Factors; Biological Markers; Biosocial; Bone Density; Cardiovascular Diseases; Caring; Centenarian; Chronic; Cognitive; Complex; Cytomegalovirus; Data; Data Files; Data Set; Dental; Dental Care; Dental caries; Diabetes Mellitus; Disease; Elderly; Ethnic Origin; Exhibits; Exposure to; Food; Gender; Health; Health Status; Health behavior; Healthcare; Healthy People 2010; Immune; Immune system; Inflammatory; Insurance; Lead; Life; Life Expectancy; Link; Mastication; Measures; Mediating; Medical; Metabolic; Minority Groups; Modeling; Mouth Diseases; National Health and Nutrition Examination Survey; Onset of illness; Oral; Oral health; Osteoporosis; Outcome; Pattern; Periodontal Diseases; Persons; Physiological; Plant Roots; Population; Prevalence; Process; Race; Research; Risk; Risk Factors; Sampling; Socioeconomic Status; Stroke; Subgroup; Symptoms; System; Time; Tooth structure; United States; United States Dept. of Health and Human Services; Visit; Xerostomia; age related; base; biopsychosocial; exhaustion; experience; health disparity; immune function; improved; interest; low socioeconomic status; member; mortality; psychologic; public health relevance; social; socioeconomics

DESCRIPTION (provided by applicant): The aim of this project is to develop a biopsychosocial model that explains how sociodemographic, biosocial, behavioral factors interact with one another to lead to differential oral health in later life. Oral aging indicators examined in this project include tooth count, tooth decay, periodontal disease, and oral symptoms such as dry mouth and difficulty chewing foods. We will examine the effect on oral aging of the proposed mechanisms including race/ethnicity, socioeconomic status, health behaviors, health care use and availability, chronic health conditions, psychological and cognitive characteristics, and biological risk factors. We will specifically examine the age patterns of the relationship between oral health and various biopsychosocial factors in order to understand the evidence of earlier aging manifested by the higher presence at a given age of oral health problems in some subgroups of the population such as the poor and members of some racial and ethnic minority groups. We are particularly interested in looking at the link between some biological risk factors and oral health including indicators of inflammatory, immune and metabolic system processes, and bone density. This project will use the National Health and Nutrition Examination Survey (NHANES) 1999-2006, and 1988-1994 for mortality-linked analyses and analyses with CMV. NHANES-mortality linked data set will allow us to develop healthy life expectancy based on oral health indicators such as years of life without periodontal disease and years of life with natural teeth. A rich set of examined dental measures and potential mechanisms including biomarkers measured in NHANES provides an unparalleled opportunity to systematically and comprehensively study how mechanisms interact with one another to produce oral health and how some groups of our population get to poorer oral health outcomes, which can be an indicator of earlier aging. PUBLIC HEALTH RELEVANCE: It is important to understand how demographic, socioeconomic, psychological, medical and biological factors interact to produce oral health disparities across population subgroups in the United States. Better understanding the mediating factors and their interactions would not only help reduce the disparities of oral health among different populations, but it would also help provide strategies to improve oral health status. In addition, given that oral health status can be related to major chronic conditions related to aging, including cardiovascular disease, diabetes and osteoporosis, it is important to understand interacting mechanisms by which oral health care and other medical care can be coordinated to improve overall health status.

描述（由申请人提供）：该项目的目的是开发一种生物心理社会模型，解释社会人口、生物社会、行为因素如何相互作用，从而导致晚年口腔健康状况的差异。该项目检查的口腔老化指标包括牙齿数量、蛀牙、牙周病以及口干和咀嚼食物困难等口腔症状。我们将研究所提出的机制对口腔衰老的影响，包括种族/民族、社会经济地位、健康行为、医疗保健的使用和可用性、慢性健康状况、心理和认知特征以及生物风险因素。我们将专门研究口腔健康与各种生物心理社会因素之间关系的年龄模式，以了解早期衰老的证据，这些证据表现为某些人口亚群体（例如穷人和某些种族和少数民族群体的成员）在特定年龄时口腔健康问题的存在率较高。我们特别感兴趣的是研究一些生物风险因素与口腔健康之间的联系，包括炎症、免疫和代谢系统过程以及骨密度的指标。该项目将使用 1999-2006 年和 1988-1994 年国家健康和营养检查调查 (NHANES) 进行死亡率相关分析和 CMV 分析。 NHANES-mortality linked data set will allow us to develop healthy life expectancy based on oral health indicators such as years of life without periodontal disease and years of life with natural teeth.一系列丰富的检查牙科措施和潜在机制，包括在 NHANES 中测量的生物标志物，提供了一个无与伦比的机会，可以系统、全面地研究机制如何相互作用以产生口腔健康，以及我们人口中的某些群体如何获得较差的口腔健康结果，这可能是早期衰老的一个指标。 公共卫生相关性：了解人口、社会经济、心理、医学和生物因素如何相互作用以产生美国不同人群的口腔健康差异非常重要。更好地了解中介因素及其相互作用不仅有助于减少不同人群之间口腔健康的差异，而且还有助于提供改善口腔健康状况的策略。此外，鉴于口腔健康状况可能与与​​衰老相关的主要慢性疾病有关，包括心血管疾病、糖尿病和骨质疏松症，因此了解协调口腔保健和其他医疗保健以改善整体健康状况的相互作用机制非常重要。