METHODS FOR THE QUANTIFICATION OF MYOCARDIAL OXYGEN CONSUMPTION WITH 17O MRI

用 17O MRI 量化心肌耗氧量的方法

• 批准号: 7739591
• 负责人: JIE ZHENG
• 金额: $ 19万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7739591
• 关键词: Anatomy; Animals; Applications Grants; Arteries; Blood; Blood flow; Blood specimen; Brain; Canis familiaris; Cardiac; Cause of Death; Cerebrum; Clinical; Contrast Media; Coronary; Coronary Arteriosclerosis; Coronary sinus structure; Detection; Developed Countries; Equilibrium; Evaluation; Goals; Gold; Heart; Heart Diseases; Human; Imaging Techniques; Injection of therapeutic agent; Intervention; Label; Laboratories; Lead; Link; Magnetic Resonance Imaging; Measurement; Measures; Mechanics; Metabolic; Methods; Microspheres; Modality; Modeling; Myocardial; Myocardium; Oxygen; Oxygen Consumption; Oxygen saturation measurement; Patient Selection; Patients; Pharmacologic Substance; Physiological; Positron-Emission Tomography; Radiation; Resolution; Series; Techniques; Tracer; Validation; base; blood flow measurement; data acquisition; direct application; imaging modality; improved; in vivo; novel; public health relevance; research study; response; stressor

DESCRIPTION (provided by applicant): Coronary artery disease (CAD) remains the leading cause of death in industrialized nations. Under normal physiological conditions, myocardial blood flow (MBF), oxygen consumption (MVO2), and myocardial mechanical function are intimately related. CAD manifests as imbalances between myocardial oxygen supply and demand. MVO2 directly reflects the balance of oxygen supply and demand of myocardium. Accurate assessment of myocardial ischemic status, particularly myocardial viability, is of paramount importance for selection of patients likely to benefit from coronary revascularization. However, detection of this status in myocardium remains an important clinical problem, partially owning to the inherent difficulty of direct measurement of MVO2 in vivo, particularly on a non-invasive and regional basis. In response to this need, our laboratory is developing a new technique to directly quantify MVO2 using non-invasive magnetic resonance imaging (MRI) T1rho techniques and 17O-enriched blood tracer. However, this technique has not been optimized and needs rigorous validation. Therefore, our overall objective is to optimize and validate this clinically viable MRI technique to measure MVO2 reliably and consistently. The goal of the application will be accomplished by pursuing a series of experiments in phantoms and a canine model. Accuracy of MVO2 measurement by MRI will be determined by comparing with gold standards such as microsphere for blood flow measurements and simultaneous blood sampling from artery and coronary sinus for the determination of myocardial global OEF. Pharmaceutical interventions will be performed to alter MVO2 in dogs. This direct assessment of metabolic activity in the myocardium may significantly improve the accuracy and precision of measurement of MVO2. Ultimately, the proposed methods may facilitate comprehensive MRI assessments of CAD and other cardiac diseases. PUBLIC HEALTH RELEVANCE: This project is to develop a new magnetic resonance imaging technique for direct quantification of myocardial oxygen consumption ratio. The technique will use T1rho imaging method and the injection of 17O-labeled blood contrast agent. Direct measurement of the oxygen consumption ratio may facilitate comprehensive evaluations of patients with a variety of cardiac diseases.

描述（由申请人提供）：冠状动脉疾病（CAD）仍然是工业化国家死亡的主要原因。在正常的生理条件下，心肌流动（MBF），氧消耗（MVO2）和心肌机械功能密切相关。 CAD表现为心肌氧和需求之间的不平衡。 MVO2直接反映了心肌的氧气供应和需求的平衡。准确评估心肌缺血状态，尤其是心肌生存力，对于选择可能受益于冠状动脉血运重建的患者至关重要。但是，对心肌中这种状态的检测仍然是一个重要的临床问题，部分拥有在体内直接测量MVO2的固有难度，尤其是在非侵入性和区域基础上。为了响应这种需求，我们的实验室正在开发一种新技术，使用非侵入性磁共振成像（MRI）T1RHO技术和17o增强的血液示踪剂直接量化MVO2。但是，该技术尚未得到优化，需要严格的验证。因此，我们的总体目标是优化和验证该临床上可行的MRI技术，以可靠，一致地测量MVO2。应用程序的目标将通过在幻影和犬模型中进行一系列实验来实现。通过MRI测量的准确性将通过与金标准品（例如微球进行血流测量值）进行比较，并从动脉和冠状窦的同时进行血液采样，以测定心肌全球OEF。将进行药物干预措施以改变狗的MVO2。对心肌代谢活性的直接评估可能会显着提高MVO2测量的准确性和精度。最终，提出的方法可能促进对CAD和其他心脏病的全面MRI评估。公共卫生相关性：该项目是开发一种新的磁共振成像技术，以直接量化心肌氧的消耗率。该技术将使用T1RHO成像法和注射17O标记的血液对比剂。直接测量氧气消耗比可能有助于对各种心脏病患者进行全面评估。