Characterization of Microcirculatory Function in Diabetic Leg and Foot with MRI

糖尿病腿部和足部微循环功能的 MRI 表征

• 批准号: 8887305
• 负责人: JIE ZHENG
• 金额: $ 20.12万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8887305
• 关键词: Address; Amputation; Ankle; Arteries; Biological Preservation; Blood flow; Clinical; Complications of Diabetes Mellitus; Data; Development; Diabetes Mellitus; Diabetic Foot Ulcer; Diabetic ulcer; Distal; Evaluation; Exercise; Foot Ulcer; Foundations; Goals; Healed; Health; Imaging Techniques; Impaired wound healing; Intervention; Investigation; Ischemia; Leg; Limb structure; Lower Extremity; Magnetic Resonance Imaging; Maps; Measures; Methods; Microcirculation; Muscle; Outcome; Outcomes Research; Oxygen; Patients; Perfusion; Peripheral Nervous System Diseases; Peripheral Vascular Diseases; Probability; Regional Perfusion; Rest; Risk; Severities; Skeletal Muscle; Techniques; Testing; Tissues; Toes; Ulcer; Ursidae Family; Veins; Wound Healing; base; calcification; clinical practice; diabetic; foot; healing; healthy volunteer; improved; indexing; novel; outcome forecast; pressure; vascular bed; volunteer; wound

DESCRIPTION (provided by applicant): Foot ulcers are an important complication of diabetes mellitus and often precede lower- extremity amputation. Insufficient perfusion of the tissues around ulcers may be the most limiting component to ulcer formation and healing. However, it is historically very difficult to assess distal leg and foot perfusion accurately. The objective of ths study is to evaluate a newly developed non-contrast MRI technique to characterize local skeletal muscle microcirculation in calf and foot. This will be performed in groups of patients with diabetes and foot ulcers, in comparison with healthy subjects and patients with peripheral vascular disease. The long term goal is to promote microcirculation as a prime evaluation target before embarking on interventional treatment for limb preservation in a patient with diabetes. Two specific aims will be addressed. Specific Aim 1 will compare the non-contrast MRI skeletal muscle perfusion and oxygenation techniques with clinical methods to assess perfusion of lower extremities. Specific Aim 2 will determine the relationships between regional skeletal muscle perfusion / oxygenation, and the presence of pedal ulcers in patients with diabetes. This will be compared with patients with peripheral vascular disease and foot ulcers, as well as with healthy volunteers. All study will be performed at rest and during a challenge exercise. It is hypothesized that these regional perfusion and oxygenation indices will be strongly associated with the severity of diabetes and presence of foot ulcer. The completion of this study will provide a foundation for further detailed understanding of the local wound perfusion, which is essential to developing a management plan and establishing prognosis.

描述（由申请人提供）：脚溃疡是糖尿病的重要并发症，通常是下肢截肢之前的。溃疡周围组织的灌注不足可能是溃疡形成和愈合的最有限的成分。但是，历史上很难准确评估远端的脚和脚灌注。 THS研究的目的是评估新开发的非对比度MRI技术，以表征小腿和脚部局部骨骼肌微循环。与健康受试者和外周血管疾病患者相比，这将在糖尿病和足部溃疡患者组中进行。长期目标是在开始进行糖尿病患者肢体保存的介入治疗之前促进微循环作为主要评估目标。 将解决两个具体目标。具体目标1将比较非对比度MRI骨骼肌灌注和氧合技术与评估下肢灌注的临床方法。具体的目标2将确定区域骨骼肌灌注 /氧合和糖尿病患者踏板溃疡的存在之间的关系。这将与周围血管疾病和足部溃疡以及健康志愿者的患者进行比较。所有研究都将在休息和挑战运动中进行。假设这些区域性灌注和氧合指数将与糖尿病的严重程度和足球溃疡的存在密切相关。这项研究的完成将提供 进一步了解当地伤口灌注的基础，这对于制定管理计划和建立预后至关重要。

项目成果

Oximetric angiosome imaging in diabetic feet.

糖尿病足的血氧血管体成像。

• DOI: 10.1002/jmri.25220
• 发表时间: 2016
• 期刊: Journal of magnetic resonance imaging : JMRI
• 作者: Zheng,Jie;Muccigrosso,David;Zhang,Xiaodong;An,Hongyu;Coggan,AndrewR;Adil,Bashir;Hildebolt,CharlesF;Vemuri,Chandu;Geraghty,Patrick;Hastings,MaryK;Mueller,MichaelJ
• 通讯作者: Mueller,MichaelJ

A pilot study of regional perfusion and oxygenation in calf muscles of individuals with diabetes with a noninvasive measure.

采用无创措施对糖尿病患者小腿肌肉局部灌注和氧合进行的初步研究。

• DOI: 10.1016/j.jvs.2013.07.115
• 发表时间: 2014
• 期刊: Journal of vascular surgery
• 影响因子: 4.3
• 作者: Zheng,Jie;Hasting,MaryK;Zhang,Xiaodong;Coggan,Andrew;An,Hongyu;Snozek,Darrah;Curci,John;Mueller,MichaelJ
• 通讯作者: Mueller,MichaelJ