NICHD Cooperative Multicenter Neonatal Research Network

描述（由申请人提供）：这份申请来自犹他大学新生儿科，申请加入多中心新生儿合作研究网络。该网络的目标是通过提供足够的病人，及时有力地回答重要的临床问题，促进对新生儿，特别是低出生体重婴儿护理的严格临床研究。犹他大学新生儿重症监护室在进一步实现这些目标方面具有独特的优势。该事业部建议为网络带来的具体优势包括：1。犹他大学新生儿科nicu每年有超过7500例新生儿，其中1800例入院。2. 教师在临床研究方面经验丰富，并渴望实现网络所体现的目标。该部门长期以来与大学的母胎医学部门保持着合作和富有成效的关系，该部门一直是母胎医学网络的模范参与者，并与新生儿科部门共享数据资源。因此，该网站在新生儿网络的参与将有利于两个网络。4. 该司可用的其他资源包括：a)犹他州人口数据库和相关数据库，调查新生儿病理遗传基础的独特资源；b)犹他大学核心设施中心；c)犹他大学GCRC；d)与其他研究网络的互动，包括儿科心脏病临床研究网络、儿科急诊应用研究网络和儿科药理学研究网络；e)山间儿科营养研究中心；盐湖县作为先锋地点和犹他大学儿科作为国家儿童研究先锋中心的参与由NICHD资助。为了展示网络如何利用这些资源来回答有关低出生体重婴儿护理的重要问题，我们提出了一项研究，验证了一种假设，即在需要机械通气的VLBW婴儿出生后第一天出现的低血压矫正中，抗利尿激素明显优于多巴胺。综上所述，本应用来自新生儿科

DESCRIPTION (provided by applicant): This application is from the Division of Neonatology at the University of Utah to join the Cooperative Multicenter Neonatal Research Network. The objective of the network is to foster rigorous clinical research on the care of newborn infants, particularly low birth weight infants, by providing sufficient patient availability to answer important clinical questions in a timely and powerful manner. The University of Utah NICUs are uniquely positioned to further these objectives. Specific strengths that the division proposes to bring to the network include: 1. The University of Utah Division of Neonatology NICUs have 1800 admissions from over 7500 deliveries annually. 2. The faculty is experienced in clinical research and eager to address the objectives exemplified by the Network. 3. The Division has long had a collegial and productive relationship with the Division of Maternal Fetal Medicine at the University, a division that has been an exemplary participant in the Maternal Fetal Medicine Network and shares data resources with the Division of Neonatology. Thus, the participation of this site in the Neonatal Network would benefit both networks. 4. Other resources available to the division include: a) the Utah Population Database and related databases, unique resources to investigate the genetic bases of newborn pathology; b) the Core Facilities Center at the University of Utah: c) the University of Utah GCRC; d) interaction with other research networks including the Pediatric Heart Disease Clinical Research Network, the Pediatric Emergency Care Applied Research Network, and the Pediatric Pharmacology Research Network; e) the Intermountain Center for Pediatric Nutrition Research; and the participation of Salt Lake County as a Vanguard Location and the University of Utah Department of Pediatrics as a possible Vanguard Center for the National Children's Study funded by NICHD. To show how these resources can be utilized by the network to answer important questions regarding the care of low birth weight infants, we propose a study testing the hypothesis that vasopressin will prove significantly better than dopamine for correction of hypotension occurring on the first day of life in VLBW infants requiring mechanical ventilation. In summary, this application from the Division of Neonatology at the University of Utah presents our commitment to use these resources in a cooperative and rigorous manner to further the mission of the NICHD Neonatal Research Network.