NICHD Cooperative Multicenter Neonatal Research Network

描述（由申请人提供）：本申请由犹他大学新生儿科提出，旨在加入合作多中心新生儿研究网络。该网络的目标是通过提供足够的患者及时有效地回答重要的临床问题，促进对新生儿（特别是低出生体重婴儿）护理的严格临床研究。犹他大学新生儿重症监护室在推进这些目标方面具有独特的优势。该部门建议为该网络带来的具体优势包括： 1. 犹他大学新生儿重症监护室 (NICU) 每年收治 7500 多例分娩中的 1800 例新生儿。 2. 教师在临床研究方面经验丰富，并渴望实现网络所例证的目标。 3. 该科与大学母胎医学科长期以来一直保持着合作和富有成效的关系，该科一直是母胎医学网络的模范参与者，并与新生儿科共享数据资源。因此，该站点参与新生儿网络将使两个网络受益。 4. 该部门可用的其他资源包括： a) 犹他州人口数据库和相关数据库，这是研究新生儿病理学遗传基础的独特资源； b) 犹他大学核心设施中心： c) 犹他大学 GCRC； d) 与其他研究网络的互动，包括小儿心脏病临床研究网络、小儿急救应用研究网络和小儿药理学研究网络； e) 山间儿科营养研究中心；盐湖县作为先锋地点和犹他大学儿科系作为国家儿童研究中心可能的先锋中心参与由 NICHD 资助。为了展示网络如何利用这些资源来回答有关低出生体重婴儿护理的重要问题，我们提出了一项研究，测试以下假设：加压素在纠正需要机械通气的 VLBW 婴儿出生第一天发生的低血压方面将明显优于多巴胺。总之，这份来自新生儿科的申请 犹他大学承诺以合作和严格的方式使用这些资源，以推进 NICHD 新生儿研究网络的使命。

DESCRIPTION (provided by applicant): This application is from the Division of Neonatology at the University of Utah to join the Cooperative Multicenter Neonatal Research Network. The objective of the network is to foster rigorous clinical research on the care of newborn infants, particularly low birth weight infants, by providing sufficient patient availability to answer important clinical questions in a timely and powerful manner. The University of Utah NICUs are uniquely positioned to further these objectives. Specific strengths that the division proposes to bring to the network include: 1. The University of Utah Division of Neonatology NICUs have 1800 admissions from over 7500 deliveries annually. 2. The faculty is experienced in clinical research and eager to address the objectives exemplified by the Network. 3. The Division has long had a collegial and productive relationship with the Division of Maternal Fetal Medicine at the University, a division that has been an exemplary participant in the Maternal Fetal Medicine Network and shares data resources with the Division of Neonatology. Thus, the participation of this site in the Neonatal Network would benefit both networks. 4. Other resources available to the division include: a) the Utah Population Database and related databases, unique resources to investigate the genetic bases of newborn pathology; b) the Core Facilities Center at the University of Utah: c) the University of Utah GCRC; d) interaction with other research networks including the Pediatric Heart Disease Clinical Research Network, the Pediatric Emergency Care Applied Research Network, and the Pediatric Pharmacology Research Network; e) the Intermountain Center for Pediatric Nutrition Research; and the participation of Salt Lake County as a Vanguard Location and the University of Utah Department of Pediatrics as a possible Vanguard Center for the National Children's Study funded by NICHD. To show how these resources can be utilized by the network to answer important questions regarding the care of low birth weight infants, we propose a study testing the hypothesis that vasopressin will prove significantly better than dopamine for correction of hypotension occurring on the first day of life in VLBW infants requiring mechanical ventilation. In summary, this application from the Division of Neonatology at the University of Utah presents our commitment to use these resources in a cooperative and rigorous manner to further the mission of the NICHD Neonatal Research Network.