NICHD Cooperative Multicenter Neonatal Research Network - Utah Center

描述(由申请者提供)：这是犹他大学新生儿科继续在合作多中心新生儿研究网络(NRN)工作的申请。NRN的目标是在护理高风险(特别是低出生体重)新生儿方面进行严格的临床研究，提供足够多样化的患者，以及时、有力和可推广的方式回答重要的临床问题。我们的NICU仍然处于有利地位，能够推动这些目标。该司提供的具体优势包括：1.在2006年周期内对该网络作出了富有成效的贡献。2.我们的NICU每年入院人数超过2,000人，现场分娩人数超过9,500人，人口结构与NRN其他地区不同。3.与我们的产妇胎儿医学司建立协作和富有成效的关系，该司是与我们共享数据和资源的NICHD产妇胎儿医学网的模范参与者。我们继续参与NRN将使这两个网络受益。4.仍有许多其他可用资源：a)犹他州人口数据库，这是调查新生儿病理表型遗传基础的独特资源；b)犹他大学CCTA和相关核心设施；d)儿科药理学方案；e)与目前由新的大学妇女和儿童研究所负责的多个其他研究网络互动，包括(但不限于)儿科心脏病临床研究网络、儿科急救应用研究网络、国家儿童研究(盐湖县是先锋中心，大学儿科系是先锋中心)、儿科医学中心和NRN。为了说明如何利用这些资源来回答低出生体重儿的重要问题，我们提出了一项研究，检验了一项假设，即对出生7天的患有一过性低甲状腺激素血症的极低出生体重儿进行甲状腺素治疗将导致18-22个月的存活率提高，而不会出现神经发育障碍。总之，这项申请代表了我们对推进NICHD NRN临床研究使命的持续承诺。

DESCRIPTION (provided by applicant): This is the application of the Division of Neonatology at the University of Utah to continue in the Cooperative Multicenter Neonatal Research Network (NRN). The NRN objective is to conduct rigorous clinical research in the care of high-risk (particularly low birth weight) newborn infants, by providing sufficient diverse patient availability to answer important clinical questions in a timely, powerful and generalizable manner. Our NICUs remain well positioned to further these objectives. Specific strengths that the Division offers include: 1. Productive contributions to the Network during the 2006 cycle. 2. More than 2,000 admissions to our NICUs and over 9,500 on-site deliveries annually, with demographic mix different from the rest of the NRN. 3. A collaborative and productive relationship with our Division of Maternal Fetal Medicine, an exemplary participant in the NICHD Maternal Fetal Medicine Network (MFMU) that shares data and resources with us. Our continued participation in the NRN will benefit both networks. 4. Numerous other available resources remain: a) Utah Population Database, a unique resource to investigate genetic bases of newborn pathologic phenotypes; b) University of Utah CCTA and associated core facilities; d) Pediatric Pharmacology Program; e) interaction with multiple other research networks now under the rubric of the new University Institute for Woman and Child, including (but not limited to) the Pediatric Heart Disease Clinical Research Network, Pediatric Emergency Care Applied Research Network, the National Children's Study (Salt Lake County is a Vanguard Location and the University Department of Pediatrics is a Vanguard Center), the MFMU, and the NRN. To show how these resources can be used to answer important questions in low birth weight infants, we propose a study testing the hypothesis that thyroxine treatment of VLBW infants >7 days old with transient hypothyroxinemia will result in improved survival without neurodevelopmental impairment at 18-22 months. In summary, this application presents our continued commitment to further the clinical research mission of the NICHD NRN.