NICHD Cooperative Multicenter Neonatal Research Network - Utah Center

描述（由申请人提供）：这是犹他大学新生儿科继续加入合作多中心新生儿研究网络（NRN）的申请。NRN的目标是在高风险（特别是低出生体重）新生儿护理方面进行严格的临床研究，通过提供足够的不同患者可用性，及时、有力和概括地回答重要的临床问题。我们的新生儿重症监护室仍有能力进一步实现这些目标。该司提供的具体优势包括：1。2006年周期内对网络作出的富有成效的贡献。2. 我们的新生儿重症监护室每年接待2000多人，现场分娩超过9500人，人口结构与NRN其他地区不同。3. 与我们的母胎医学部建立了合作和富有成效的关系，该学部是NICHD母胎医学网络（MFMU）的典范参与者，与我们共享数据和资源。我们继续参与NRN将使两个网络都受益。4. 许多其他可用的资源仍然存在：a)犹他州人口数据库，一个独特的资源来调查新生儿病理表型的遗传基础；b)犹他大学CCTA及相关核心设施；d)儿科药理学项目；e)在新的大学妇女和儿童研究所的标题下与多个其他研究网络进行互动，包括（但不限于）儿科心脏病临床研究网络，儿科急诊应用研究网络，国家儿童研究（盐湖城县是一个先锋地点，大学儿科系是一个先锋中心），MFMU和NRN。为了展示这些资源如何用于回答低出生体重婴儿的重要问题，我们提出了一项研究，验证了一种假设，即对bb0 ~ 7天大的VLBW婴儿进行甲状腺素治疗，可提高18-22个月时无神经发育障碍的生存率。总之，这一申请表明我们继续致力于进一步履行NICHD NRN的临床研究使命。

DESCRIPTION (provided by applicant): This is the application of the Division of Neonatology at the University of Utah to continue in the Cooperative Multicenter Neonatal Research Network (NRN). The NRN objective is to conduct rigorous clinical research in the care of high-risk (particularly low birth weight) newborn infants, by providing sufficient diverse patient availability to answer important clinical questions in a timely, powerful and generalizable manner. Our NICUs remain well positioned to further these objectives. Specific strengths that the Division offers include: 1. Productive contributions to the Network during the 2006 cycle. 2. More than 2,000 admissions to our NICUs and over 9,500 on-site deliveries annually, with demographic mix different from the rest of the NRN. 3. A collaborative and productive relationship with our Division of Maternal Fetal Medicine, an exemplary participant in the NICHD Maternal Fetal Medicine Network (MFMU) that shares data and resources with us. Our continued participation in the NRN will benefit both networks. 4. Numerous other available resources remain: a) Utah Population Database, a unique resource to investigate genetic bases of newborn pathologic phenotypes; b) University of Utah CCTA and associated core facilities; d) Pediatric Pharmacology Program; e) interaction with multiple other research networks now under the rubric of the new University Institute for Woman and Child, including (but not limited to) the Pediatric Heart Disease Clinical Research Network, Pediatric Emergency Care Applied Research Network, the National Children's Study (Salt Lake County is a Vanguard Location and the University Department of Pediatrics is a Vanguard Center), the MFMU, and the NRN. To show how these resources can be used to answer important questions in low birth weight infants, we propose a study testing the hypothesis that thyroxine treatment of VLBW infants >7 days old with transient hypothyroxinemia will result in improved survival without neurodevelopmental impairment at 18-22 months. In summary, this application presents our continued commitment to further the clinical research mission of the NICHD NRN.