NICHD Cooperative Multicenter Neonatal Research Network - Utah Center

描述（由申请人提供）：这是犹他州大学新生儿科继续参与合作多中心新生儿研究网络（NRN）的申请。NRN的目标是在高风险（特别是低出生体重）新生儿的护理中进行严格的临床研究，通过提供足够的多样化患者可用性，以及时，有力和普遍的方式回答重要的临床问题。我们的新生儿重症监护室仍处于有利地位，以进一步实现这些目标。该司提供的具体优势包括：1。在2006年周期内对网络作出建设性贡献。2.我们的NICU每年有2，000多名住院患者，每年有9，500多名现场分娩，人口结构与NRN的其他地区不同。3.与我们的母胎医学部门建立合作和富有成效的关系，该部门是NICHD母胎医学网络（MFMU）的典范参与者，与我们共享数据和资源。我们继续参与NRN将使这两个网络受益。4.许多其他可用的资源仍然存在：a）犹他州人口数据库，一个独特的资源，以调查遗传基础的新生儿病理表型; B）大学的犹他州CCTA和相关的核心设施; d）儿科药理学计划;（e）与目前在新的大学妇女和儿童研究所名下的多个其他研究网络进行互动，包括（但不限于）儿科心脏病临床研究网络、儿科急诊应用研究网络、全国儿童研究（盐湖县是一个先锋位置和儿科大学系是一个先锋中心），MFMU，和NRN。为了说明如何利用这些资源来回答低出生体重儿的重要问题，我们提出了一项研究，以检验以下假设：甲状腺素治疗>7天的极低出生体重儿伴一过性甲状腺素低血症将导致18-22个月时无神经发育障碍的生存率提高。总之，本申请表明我们继续致力于推进NICHD NRN的临床研究使命。

DESCRIPTION (provided by applicant): This is the application of the Division of Neonatology at the University of Utah to continue in the Cooperative Multicenter Neonatal Research Network (NRN). The NRN objective is to conduct rigorous clinical research in the care of high-risk (particularly low birth weight) newborn infants, by providing sufficient diverse patient availability to answer important clinical questions in a timely, powerful and generalizable manner. Our NICUs remain well positioned to further these objectives. Specific strengths that the Division offers include: 1. Productive contributions to the Network during the 2006 cycle. 2. More than 2,000 admissions to our NICUs and over 9,500 on-site deliveries annually, with demographic mix different from the rest of the NRN. 3. A collaborative and productive relationship with our Division of Maternal Fetal Medicine, an exemplary participant in the NICHD Maternal Fetal Medicine Network (MFMU) that shares data and resources with us. Our continued participation in the NRN will benefit both networks. 4. Numerous other available resources remain: a) Utah Population Database, a unique resource to investigate genetic bases of newborn pathologic phenotypes; b) University of Utah CCTA and associated core facilities; d) Pediatric Pharmacology Program; e) interaction with multiple other research networks now under the rubric of the new University Institute for Woman and Child, including (but not limited to) the Pediatric Heart Disease Clinical Research Network, Pediatric Emergency Care Applied Research Network, the National Children's Study (Salt Lake County is a Vanguard Location and the University Department of Pediatrics is a Vanguard Center), the MFMU, and the NRN. To show how these resources can be used to answer important questions in low birth weight infants, we propose a study testing the hypothesis that thyroxine treatment of VLBW infants >7 days old with transient hypothyroxinemia will result in improved survival without neurodevelopmental impairment at 18-22 months. In summary, this application presents our continued commitment to further the clinical research mission of the NICHD NRN.