MEASUREMENT AND IMAGING CORE

测量和成像核心

• 批准号: 7699807
• 负责人: JAMES Anthony ASHTON-MILLER
• 金额: $ 22.45万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7699807
• 关键词: Area; Behavior; Biomedical Engineering; Catheters; Cesarean section; Clinical; Closure; Computer software; Condition; Data; Data Set; Image; Magnetic Resonance; Magnetic Resonance Imaging; Measurement; Measures; Modeling; Muscle; Operative Surgical Procedures; Pelvic Floor Muscle; Pelvic floor structure; Pelvis; Property; Recovery; Second Labor Stage; Signal Transduction; Speculums; Time; Urethra; Vagina; Weight; Woman; instrument; levator ani muscle; muscle strength; pressure; reconstruction

The Measurement and Imaging Core will assist with measurements of perineal geometry during the late second stage of labor in 50 women, and of pelvic floor load-displacement behavior in 32 women using a posterior weighted speculum at the time of pelvic surgery. The Core will assist with clinical measurements and standardized data sets from magnetic resonance (MR) imaging to be made on the 175 and 150 women completing Projects 2 and 3, respectively. In Projects 2 & 3, subject-specific pelvic floor model geometries will be developed from reconstructing the magnetic resonance (MR) images. Additionally, in Project 2 the post natal recovery of normal MR signal intensity will be tracked over time in the pubovisceral muscles. In Project 3, MR measurements of posterior vaginal wall geometry will be made. Lastly, the Core will provide bioengineering and technical support to each project. For Projects 2 & 3 it will provide technical support for all urethral pressure measurements (MUCPR and MUCPMvc) to be made using 8F catheter, maintain the hardware and software of the instrumented speculum used to measure levator ani contractile properties (LAR and I_AMVC,), and analyze and provide cleaned data sets to Core A for statistical analysis.

测量和成像核心将在后期协助测量会阴几何形状 第二产程50例，骨盆底负荷-位移行为的32例妇女使用一个 骨盆手术时使用后加重窥镜。核心将协助临床测量 以及对175名和150名妇女进行磁共振（MR）成像的标准化数据集 分别完成项目2和项目3。在项目2和3中，受试者特定的骨盆底模型几何形状 将从重建磁共振（MR）图像中开发。此外，在项目2中， 将在耻骨内脏肌中随时间跟踪正常MR信号强度的纳塔尔后恢复。在 项目3，将进行阴道后壁几何结构的MR测量。最后，核心将提供 生物工程和技术支持每个项目。对于项目2和3，它将提供技术支持， 使用8 F导管进行所有尿道压力测量（MUCPR和MUCPMvc），保持 用于测量肛提肌收缩特性（LAR）的仪器化窥器的硬件和软件 和I_AMVC），并分析和提供清洁的数据集给核心A用于统计分析。