Biomechanics Core

生物力学核心

• 批准号: 10221527
• 负责人: JAMES Anthony ASHTON-MILLER
• 金额: $ 18.37万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10221527
• 关键词: Affect; Aging; American; American Heart Association; Applications Grants; Award; Biological Markers; Biomechanics; Blood Vessels; Blood Volume; Capsicum; Cardiac; Collaborations; Computer Models; Consult; Data; Development; Diabetes Mellitus; Diagnosis; Disease; Economics; Elderly; Encephalopathies; Engineering; Equilibrium; Equipment; Extramural Activities; Extravasation; Faculty; Functional disorder; Geriatrics; Goals; Grant; Health; Impairment; Individual; Indwelling Catheter; Inflammation; Institution; Interdisciplinary Study; Internal Medicine; Intervention; Kidney Failure; Laboratory Research; Life Style; Liver Cirrhosis; Measurement; Measures; Mechanics; Mentorship; Metabolic Diseases; Methods; Modeling; Modification; Non-Insulin-Dependent Diabetes Mellitus; Outcome; Outcome Measure; Output; Patients; Peer Review; Physical activity; Physicians; Physiological; Prevention; Productivity; Ptosis; Renal function; Research; Research Personnel; Research Project Grants; Risk; SECTM1 gene; Self Management; Services; Severities; Smooth Muscle; Sodium; Stream; Striated Muscles; Structure; System; Technology Transfer; Testing; Time; Training; Urethra; Urethral sphincter; Urinary Incontinence; Urine; Validation; age related; bench to bedside; black men; career development; comorbidity; computerized data processing; data acquisition; decubitus ulcer; design; fall injury; falls; functional status; hip replacement arthroplasty; improved; insight; interest; invention; investigator training; mathematical model; microsensor; models and simulation; motion sensor; novel; older women; pathomechanics; pelvic organ prolapse; prevent; processing speed; programs; ranpirnase; research clinical testing; software systems; sphincter ani muscle structure; success; wearable sensor technology

ABSTRACT The Biomechanics Core (BC) will facilitate the training of investigators in the conduct of new and expanded research on how metabolic disease and inflammation interact with age-related disease to determine key health outcomes. The Specific Aims include: providing interdisciplinary expertise, training and technical support for the biomechanical and other physiological aspects of Research Career Development, a Pilot Exploratory Study, a Developmental Project (DP) and 8 External Projects (EPs, Aim 1); providing individual guidance on (Aim 2) and evaluating methods (Aim 3) related to mobility and functional status, the biomechanics of aging, and to the training of geriatric physicians and other clinicians in the biomechanics relevant to impaired mobility, falls and fall-related injuries, urinary incontinence and prolapse in the older adults; and assisting with computer modeling and simulation related to the above goals (Aim 4). BC-supported investigators will have substantial access to the UM Biomechanics Research Laboratory of the Department of Mechanical Engineering and the Mobility Research Center at the UM Geriatrics Center. The DP will enhance a BC-invented uroflowmeter by designing and testing a microsensor to measure mid-stream urine sodium in real time. This modification will challenge the existing paradigm of needing an indwelling catheter to accurately measure urine output and urine biomarkers, and the invention will help differentiate kidney failure from normal kidney function with low blood volume. The EPs include improving the treatment of hip arthroplasty, urinary incontinence and pelvic organ prolapse, preventing decubitus ulcers, and wearable sensors to determine real world physical activity and falls in older adults. By structuring the BC as a separate Core, the OAIC achieves economic efficiencies in terms of reduced equipment and service that would be duplicated if separate biomechanics components were pursued by individual OAIC projects. Since its inception, the BC has served as a consulting service to faculty performing multidisciplinary research on geriatric mobility problems. Consequently, the BC has positively impacted the quality of the research conducted in and beyond the OAIC, as demonstrated by its productivity in terms of peer-reviewed articles, the success of young investigators granted with K08, K12, K23, K99/R00 awards, and extramural research projects awarded by R03, R21, R01, P50 and RC2 mechanisms.

摘要 生物力学核心（BC）将促进研究者在进行新的和扩展的 研究代谢疾病和炎症如何与年龄相关疾病相互作用，以确定关键健康 结果。具体目标包括：提供跨学科的专门知识、培训和技术支持， 研究职业发展的生物力学和其他生理学方面，一个试点探索 研究，一个发展项目（DP）和8个外部项目（EP，目标1）;提供个人指导， (Aim 2）和评估方法（目的3）有关的流动性和功能状态，老化的生物力学， 并且涉及老年内科医生和其他临床医生在与运动障碍相关的生物力学方面的培训， 老年人的福尔斯和跌倒相关损伤、尿失禁和脱垂;以及计算机辅助 与上述目标相关的建模和模拟（目标4）。BC支持的调查人员将有大量的 进入机械工程系的UM生物力学研究实验室和 移动研究中心在UM老年病中心。DP将增强BC发明的尿流量计， 设计并测试了一种微传感器，用于真实的实时测量中段尿钠。这一修改将 需要留置导管来准确测量尿量和尿量 生物标志物，并且本发明将有助于区分肾衰竭与具有低血容量的正常肾功能 音量.包括改善髋关节置换术、尿失禁和盆腔器官的治疗 脱垂，预防褥疮溃疡，以及可穿戴传感器，以确定真实的世界身体活动和福尔斯 在老年人中。通过将BC构建为单独的核心，OAIC在以下方面实现了经济效率： 如果采用单独的生物力学组件，将减少重复的设备和服务 OAIC的个别项目。自成立以来，BC一直为教师提供咨询服务 对老年人的流动性问题进行多学科研究。因此，BC积极地 影响了在OAIC内外进行的研究的质量，正如其在 就同行评审文章而言，年轻研究者获得K 08、K12、K23、K99/R 00的成功 R 03、R21、R 01、P50和RC 2机制颁发的各种奖学金和校外研究项目。