Reflex Regulation of Motor function in Human SCI

人类 SCI 中运动功能的反射调节

• 批准号: 7784830
• 负责人: Thomas George Hornby
• 金额: $ 39.44万
• 依托单位: MARQUETTE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-20 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7784830
• 关键词: Activities of Daily Living; Affect; Agonist; Baclofen; Behavior; Clinical Management; Dose; Functional disorder; Gait; Generations; Guidelines; Human; Knowledge; Leg; Lower Extremity; Motor; Motor output; Movement; Muscle; Oral; Pathway interactions; Patients; Performance; Pharmaceutical Preparations; Play; Reducing Agents; Reflex action; Regulation; Rehabilitation therapy; Research Project Grants; Role; Sensory; Spasm; Spastic; Spinal; Spinal cord injury; Spinal cord injury patients; Testing; Therapeutic; Time; Walking; depressed; depression; improved; motor control; noradrenergic; rehabilitation strategy; response; sensory feedback; tizanidine

The objective of this study is to identify how the suppression of reflex function by antispastic agents affects volitional movement in people with incomplete spinal cord injury (SCI). Spastic reflexes are commonly treated using medications or other therapeutic approaches without a good understanding of how the subsequent changes in reflex function affect volitional movements, including gait. This study aims to improve our understanding of how reflexes affect functional movements and the impact that oral medications have on reflex regulation of movement in people with incomplete SCI. We will test the effect of two commonly prescribed antispastic oral medications, baclofen and tizanidine, on the reflex regulation of volitional muscle activity and gait. We expect that reflex excitation contributes to the generation of muscle activity during volitional tasks, and antispastic agents will depress reflexes and reduce muscle activity of the legs during gait. A comparison of the effects of reflexes on volitional movements, including gait, and sensitivity to antispastic agents will be made to gain an improved understanding of how different types of incomplete SCI patients utilize reflex activation of muscles to facilitate movement. We anticipate that subjects with greater weakness might rely heavily on reflexes for the generation of muscle activity during movement, and could be detrimentally affected by antispastic medications. This study has important implications for therapies aimed at restoring movement in SCI and for the treatment of spasticity to improve functional movements.

本研究的目的是确定抗痉挛药物抑制反射功能如何影响 不完全脊髓损伤（SCI）患者的意志运动。痉挛反射通常被治疗 在没有充分了解后续效果的情况下使用药物或其他治疗方法 反射功能的变化影响意志运动，包括步态。这项研究旨在提高我们 了解反射如何影响功能性运动以及口服药物对反射的影响 不完全 SCI 患者的运动调节。我们将测试两种常用处方的效果 抗痉挛口服药物巴氯芬和替扎尼定对意志肌肉活动的反射调节和 步态。我们期望反射兴奋有助于在意志任务期间产生肌肉活动，并且 抗痉挛剂会抑制反射并减少步态期间腿部的肌肉活动。比较 将研究反射对意志运动（包括步态）和对抗痉挛药物的敏感性的影响 更好地了解不同类型的不完全性 SCI 患者如何利用反射激活 肌肉以促进运动。我们预计弱点较大的受试者可能会严重依赖 运动过程中产生肌肉活动的反射，并且可能受到以下因素的不利影响 抗痉挛药物。这项研究对于旨在恢复运动的治疗具有重要意义 SCI 并用于治疗痉挛以改善功能性运动。