A Distributed Wireless Neural Interface System

描述（由申请人提供）：该拨款建议开发和测试一个高度先进的神经接口系统，该系统将现代神经接口的最佳功能整合到单个系统中。微型神经接口（MNI）系统由多达100个独立的无线生物传感器组成，具有机载信号调节和尖峰检测功能。每个探头通过2.4 GHz无线射频收发器通信并供电。单个探针可以植入皮层和皮层下结构。MNI系统有两种工作模式：时间戳和流。在时间戳模式下，按顺序查询每个MNI探针，以便每1000秒收集一次来自所有探针的数据。每个探头独立编程与两个阈值设置，以提供基本的尖峰辨别。在流模式下，单个探头将以8位分辨率以10khz数字化的神经数据传输到基站。这种模式允许用户检查尖峰波形并在外部PC上执行手动尖峰排序，但它一次只能处理单个探头。在流模式期间还传输阈值交叉点以允许功能验证。提出了本研究的两个具体目标：(1)开发无线微神经接口（MNI）探针和基站。SA2) MNI系统在啮齿动物体内的实验研究。这项工作对人类健康的意义在于，它将导致一种高度新颖的神经接口设计。首先，MNI系统将为研究人员和潜在的临床医生提供通过皮层和皮层下结构获得神经活动的无与伦比的途径。这将使科学家能够了解分布式神经处理，并为更深入地了解神经系统疾病提供工具。其次，MNI系统可以用作脑机接口。

DESCRIPTION (provided by applicant): This grant proposes the development and testing of a highly advanced neural interface system that incorporates the best features of modern neural interfaces into a single system. The Micro Neural Interface (MNI) system is comprised of up to 100 independent, wireless, biological sensors with on-board signal conditioning and spike detection. Each probe communicates with and is powered via a 2.4 GHz wireless RF transceiver. Individual probes can be implanted within cortical and subcortical structures. The MNI system has two operating modes: time stamp and streaming. In time stamp mode, each MNI probe is queried sequentially such that data from all probes is collected every 1000 5s. Each probe is independently programmed with two threshold settings to provide basic spike discrimination. In the streaming mode, a single probe transmits neural data that is digitized with 8 bits of resolution at 10 KHz to a basestation. This mode allows the user to examine the spike waveforms and perform manual spike sorting on an external PC, but it can address only a single probe at a time. Threshold crossings are also transmitted during the streaming mode to allow functional verification. Two specific aims are proposed for this research SA1) Development of wireless Micro-Neural Interface (MNI) probes and basestation. SA2) In-vivo testing of the MNI system in rodents. PUBLIC HEALTH RELEVANCE: Narrative The significance of this work to human health is that it will result in a highly novel neural interface design. First, the MNI system will provide researchers and potentially clinicians with unparalleled access to neural activity across cortical and subcortical structures. This access will allow scientist to understand distributed neural processing and provide a tool for more in-depth understanding of neurological disorders. Second, the MNI system may be used as a Brain Machine Interface.