A Distributed Wireless Neural Interface System

描述（由申请人提供）：该资助提出了一个高度先进的神经接口系统的开发和测试，该系统将现代神经接口的最佳功能整合到一个单一的系统中。 微神经接口（MNI）系统由多达100个独立的无线生物传感器组成，具有板载信号调节和尖峰检测功能。 每个探头与2.4 GHz无线RF收发器通信并通过其供电。 单个探头可植入皮质和皮质下结构。 MNI系统有两种工作模式：时间戳和流。 在时间戳模式下，每个MNI探头按顺序查询，以便每1000 5s收集一次来自所有探头的数据。 每个探头都独立编程为两个阈值设置，以提供基本的尖峰鉴别。 在流模式下，单个探头将以10 KHz的8位分辨率数字化的神经数据传输到基站。 此模式允许用户检查尖峰波形并在外部PC上执行手动尖峰排序，但它一次只能寻址单个探头。 在流式传输模式期间还传输阈值交叉以允许功能验证。 本研究提出了两个具体目标SA1）无线微神经接口（MNI）探头和基站的开发。 SA2）MNI系统在啮齿动物中的体内测试。 公共卫生相关性：叙述这项工作对人类健康的意义在于，它将导致一种非常新颖的神经接口设计。 首先，MNI系统将为研究人员和潜在的临床医生提供无与伦比的跨皮层和皮层下结构的神经活动。 这种访问将使科学家能够了解分布式神经处理，并为更深入地了解神经系统疾病提供工具。 第二，MNI系统可以用作脑机接口。

DESCRIPTION (provided by applicant): This grant proposes the development and testing of a highly advanced neural interface system that incorporates the best features of modern neural interfaces into a single system. The Micro Neural Interface (MNI) system is comprised of up to 100 independent, wireless, biological sensors with on-board signal conditioning and spike detection. Each probe communicates with and is powered via a 2.4 GHz wireless RF transceiver. Individual probes can be implanted within cortical and subcortical structures. The MNI system has two operating modes: time stamp and streaming. In time stamp mode, each MNI probe is queried sequentially such that data from all probes is collected every 1000 5s. Each probe is independently programmed with two threshold settings to provide basic spike discrimination. In the streaming mode, a single probe transmits neural data that is digitized with 8 bits of resolution at 10 KHz to a basestation. This mode allows the user to examine the spike waveforms and perform manual spike sorting on an external PC, but it can address only a single probe at a time. Threshold crossings are also transmitted during the streaming mode to allow functional verification. Two specific aims are proposed for this research SA1) Development of wireless Micro-Neural Interface (MNI) probes and basestation. SA2) In-vivo testing of the MNI system in rodents. PUBLIC HEALTH RELEVANCE: Narrative The significance of this work to human health is that it will result in a highly novel neural interface design. First, the MNI system will provide researchers and potentially clinicians with unparalleled access to neural activity across cortical and subcortical structures. This access will allow scientist to understand distributed neural processing and provide a tool for more in-depth understanding of neurological disorders. Second, the MNI system may be used as a Brain Machine Interface.