Comprehensive NAU/AZCC Cancer Research Partnership

NAU/AZCC 癌症研究综合合作伙伴关系

• 批准号: 7691872
• 负责人: Diane M Stearns
• 金额: $ 20万
• 依托单位: NORTHERN ARIZONA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-20 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7691872
• 关键词: Address; American Indians; Arizona; Basic Science; Cancer Center; Chemicals; Clinical Trials; Collaborations; Communities; Community Outreach; Data; Development; Education and Outreach; Effectiveness; Face; Faculty; Future; Health Personnel; Healthcare; Industry; Institution; Link; Malignant Neoplasms; Mining; NCI Center for Cancer Research; Native Americans; Oncologist; Patients; Pilot Projects; Provider; Rate; Recording of previous events; Recruitment Activity; Research; Research Activity; Research Personnel; Reservations; Students; Training; Training Programs; Universities; anticancer research; cancer diagnosis; cancer education; career; improved; interest; mortality; programs

DESCRIPTION: (Applicant?s Description) In the face of improved US cancer survival, cancer mortality in American Indians is increasing. Cultural differences make addressing this disparity challenging. The paucity of American Indian health care providers, almost none oncologists, compounds the situation. American Indian patients, unable to effectively communicate with providers, become isolated from cancer diagnosis and treatment and are rarely recruited into clinical trials. While the need for American Indian oncologists is therefore urgent, few American Indians enter health care professions. While most universities have dismal recruitment and retention rates, Northern Arizona University (NAU) has a distinguished history of graduating Native American students. At NAU, however, there is no cancer research core to provide cancer education to American Indian students and communities. In this partnership, we will link research programs of the Arizona Cancer Center (AZCC) with American Indian student training programs and environmental research at NAU. While informal faculty interaction exists, there is currently no comprehensive plan to enhance cancer research at NAU or to coordinate American Indian student recruitment and retention at NAU and UofA/AZCC. The objectives of this proposal are to (1)initiate robust cancer research at NAU to enhance faculty career development and train students in cancer research fundamentals; (2) create stable, long-term cancer research, education, and outreach collaboration; and (3) improve institutional effectiveness in impacting the disparity in cancer in American Indians of the Southwest. Research programs will focus on the carcinogenic effects of chemicals associated with the mining industry on reservations. American Indian students have a vital interest in the data. Thus this vested interest greatly enhances our potential to recruit and retain these students and to provide future American Indian cancer researchers and oncologists. The program is guided by administrative, planning and developmental cores at each institution. Research activities include basic science, cancer education, and community outreach components. We propose 6 pilot projects, 4 full projects, and recruitment of 2 new faculty over the project lifetime.

描述:(申请人?面对改善的美国癌症

项目成果

FlgM proteins from different bacteria exhibit different structural characteristics.

• DOI: 10.1016/j.bbapap.2013.01.010
• 发表时间: 2013-04
• 期刊: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
• 影响因子: 3.2
• 作者: Ma, Wai Kit;Hendrix, Rachel;Stewart, Claire;Campbell, Eric V.;Lavarias, Mitchell;Morris, Kolyn;Nichol, Shauna;Gage, Matthew J.
• 通讯作者: Gage, Matthew J.

Characterization of PM(2.5) collected during broadcast and slash-pile prescribed burns of predominately ponderosa pine forests in northern Arizona.

• DOI: 10.1016/j.atmosenv.2011.01.051
• 发表时间: 2011-04
• 期刊: ATMOSPHERIC ENVIRONMENT
• 影响因子: 5
• 作者: Robinson, Mann S.;Zhao, Min;Zack, Lindsay;Brindley, Christine;Portz, Lillian;Quarterman, Matthew;Long, Xiufen;Herckes, Pierre
• 通讯作者: Herckes, Pierre

Toxicity of depleted uranium complexes is independent of p53 activity.

• DOI: 10.1016/j.jinorgbio.2010.10.010
• 发表时间: 2011-02
• 期刊: JOURNAL OF INORGANIC BIOCHEMISTRY
• 影响因子: 3.9
• 作者: Heintze, Ellie;Aguilera, Camille;Davis, Malia;Fricker, Avery;Li, Qiang;Martinez, Jesse;Gage, Matthew J.
• 通讯作者: Gage, Matthew J.

Conformational detection of p53's oligomeric state by FlAsH Fluorescence.

通过 FlaAsH 荧光对 p53 寡聚状态进行构象检测。

• DOI: 10.1016/j.bbrc.2009.04.073
• 发表时间: 2009
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Webber,TawnyaM;Allen,AndrewC;Ma,WaiKit;Molloy,RhettG;Kettelkamp,CharisseN;Dow,CaitlinA;Gage,MatthewJ
• 通讯作者: Gage,MatthewJ

Photoactivated uranyl ion produces single strand breaks in plasmid DNA.

• DOI: 10.1021/tx200410x
• 发表时间: 2011-11-21
• 期刊: Chemical research in toxicology
• 影响因子: 4.1
• 作者: George SA;Whittaker AM;Stearns DM
• 通讯作者: Stearns DM