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Core Laboratory for Neuromolecular Production

神经分子生产核心实验室

基本信息

批准号：
7674153
负责人：
charles mark thompson
金额：
$ 47.74万
依托单位：
UNIVERSITY OF MONTANA
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-06-01 至 2013-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7674153
关键词：
Abbreviations Address Archives Award Centers of Research Excellence Central Nervous System Diseases Chemistry Collaborations Commit Computer Simulation Consultations Core Facility Data Databases Development Ensure Environment Faculty Goals Health Occupations Health Professional Histology Human Resources Image Improve Access Individual Investigation Investments Isotopes Label Laboratories Libraries Ligands Mass Spectrum Analysis Molecular Molecular Computations Montana Neurosciences Neurotransmitters Pharmaceutical Preparations Pharmacology Positioning Attribute Preparation Problem Solving Production Proteins Proteomics Public Health Quality Control Range Reagent Request for Applications Research Research Personnel Resources Science Services Spectrum Analysis Structure Training Universities Work base cheminformatics college concept cost design experience imaging probe neurochemistry peptide structure programs repository scale up small molecule tool

项目摘要

This application will establish a Core Laboratory in Neuromolecular Production (CLNP) that provides neuroscience researchers with customized small molecule tools, consultation, resources and support to assist and advance their investigations. The Core Laboratory in Neuromolecular Production will establish and maintain essential chemistry support for neuroscience investigators including the preparation, optimization, purification and/or separation of small molecule reagents, probes and/or targets that are focused on neurotransmitter-based structures. The CLNP will undertake the synthesis of bioactive ligands, cross-linkers, isotope enriched structures, peptides, structure and imagine probes, protein-tags and bioconjugates, library development (target- and diversity-oriented syntheses), and other molecular ensembles. The CLNP will be achieved with the addition of new space, creation of a dedicated CLNP lab and program suite, a teamwork-oriented administration, workgroup-based problem solving, integration with existing cores, and the hiring of highly trained chemistry personnel to design, maintain, and execute the requested projects and services. The long-range objectives are to advance the CLNP as a dependable and sustainable service and resource to neuroscience investigators that introduces small molecule archives (warehouse) and chemoinformatic databases capable of generating new research avenues. The specific aims of this application are to: (1) design, build, and launch a Core Laboratory in Neuromolecular Production, (2) provide neuroscience investigators with customized neurotransmitter-based, ligands, probes, bioconjugates and resources to aid and enhance their existing, pending and planned NINDS-based research programs, (3) develop workgroups that promote collaborations and multi-laboratory problem solving using neurotransmitter-based ligands, probes and bioconjugates, and (4) create, manage and disseminate for public use a cheminformatic database and repository of neurotransmitter-based ligands, probes and bioconjugates. Public Health Relevance: This application seeks to develop a facility that provides customized small molecules to neuroscientists. Small molecule development is an essential first step toward developing drugs that may be helpful in battling CNS diseases.

这个应用程序将建立一个核心实验室在神经分子生产（CLNP），提供