Effect of Contralateral Leg on Motor Output Post Stroke

项目概述：本次导师研究科学家发展奖的目的是为 希望在医学康复研究领域取得长期成功的候选人。应聘者将收到 来自高级科学家的主要赞助，他将为候选人提供一段时间的密集、 重点训练运动皮质神经生理学、中风后运动皮质可塑性，以及 使用经颅磁刺激作为测量皮质兴奋性的研究工具。目的 这项研究的目的是确定患有后遗症的个体双侧腿控制的机制。 中风偏瘫；具体地说，确定一条腿的感觉运动状态对运动的影响。 另一条腿的行为。将进行三项研究以确定：1)是否会损坏马达 大脑皮质比单侧踝关节周期性运动更能引起双侧特定的功能障碍？2)在多大程度上 同侧非交叉皮质脊髓通路有助于单侧和双侧周期性踝关节运动。 运动性皮质卒中患者？3)运动皮质受损是否损害双侧小腿运动？ 行走过程中对一种新的单边扰动的反应？为了回答这些问题，3-D运动 运动学和肌电记录将记录由运动皮质引起的偏瘫患者。 中风和健康的年龄和性别匹配的对照组受试者进行脚踝运动任务和 走路。结果将有助于解释运动皮质和皮质脊髓通路的特定功能，并将 为开发新的康复技术恢复正常运动功能提供了基础 在中风后偏瘫患者中。该计划中提供的指导将有助于指导 作为一名调查员，候选人走向独立，并在候选人的长期- 理解人体运动中肢体间协调的术语研究目标和机制 神经损伤后运动功能的恢复。 相关性：这项研究将对公共健康产生广泛影响，因为中风是导致长期中风的主要原因。 由于长期残疾，许多受害者在没有援助的情况下无法行走(AHA 2005)。调查结果来自 这些研究有望帮助开发旨在中风康复的新疗法 一般情况下，特别是步态恢复。

PROJECT SUMMARY: The purpose of this Mentored Research Scientist Development Award is to prepare the candidate for a successful long-term career in medical rehabilitative research. The candidate will receive primary sponsorship from a senior-level scientist who will provide the candidate with a period of intensive, focused training in the areas of motor cortical neurophysiology, motor cortical plasticity following stroke, and the use of transcranial magnetic stimulation as a research tool to measure cortical excitability. The purpose of the research proposed here is to determine mechanisms of bilateral leg control in individuals with post- stroke hemiparesis; specifically, to determine the effects of the sensorimotor state of one leg on the motor behavior of the opposite leg. Three studies will be undertaken to determine: 1) does damage to the motor cortex cause specific deficits in bilateral more than unilateral cyclical ankle movements? 2) to what extent do ipsilateral uncrossed corticospinal pathways contribute to unilateral and bilateral cyclical ankle movements in individuals with motor cortical stroke? and 3) does damage to the motor cortex impair bilateral leg motor responses to a novel unilateral perturbation during walking? To answer these questions, 3-D movement kinematics and electromyography will be recorded from subjects with hemiparesis caused by motor cortical stroke and healthy age- and gender-matched control subjects performing ankle movement tasks and walking. Results will help explain the specific function of the motor cortex and corticospinal pathway and will provide a basis for the development of novel rehabilitation techniques to recover normal locomotor function in individuals with post-stroke hemiparesis. The mentorship provided in this plan will help direct the candidate toward independence as an investigator and lend significant progress toward the candidate's long- term research goal of understanding interlimb coordination during human locomotion and mechanisms for recovery of locomotor function following neurological damage. RELEVANCE: This research will have broad impact on public health, as stroke is a leading cause of long- term disability and leaves many of its victims unable to walk without assistance (AHA 2005). Findings from these studies are expected to help lead to the development of new treatments aimed at stroke rehabilitation generally and gait recovery specifically.