Effect of Contralateral Leg on Motor Output Post Stroke

项目摘要：这个指导研究科学家发展奖的目的是准备 在医学康复研究方面成功的长期职业生涯的候选人。候选人将获得 来自高级科学家的主要赞助，该科学家将为候选人提供一段时间的密集， 在运动皮层神经生理学、卒中后运动皮层可塑性等领域进行集中训练， 使用经颅磁刺激作为测量皮质兴奋性的研究工具。目的 的研究提出这里是确定机制的双边腿控制的个人后， 中风偏瘫;具体地说，以确定一条腿的感觉运动状态对运动的影响 另一条腿的动作。将进行三项研究，以确定：1）是否损害电机 皮质造成的特异性双侧踝关节功能缺损多于单侧踝关节周期性运动？2)在多大程度上 同侧不交叉的皮质脊髓通路有助于单侧和双侧周期性踝关节运动， 运动皮层中风的患者吗运动皮层损伤是否会损害双侧下肢运动 在行走过程中对新的单侧扰动的反应？为了回答这些问题，三维运动 运动学和肌电图将从运动皮层引起的轻偏瘫的受试者中记录， 中风和健康的年龄和性别匹配的对照受试者进行踝关节运动任务， 走路结果将有助于解释运动皮层和皮质脊髓通路的特殊功能， 为开发新的康复技术以恢复正常运动功能提供基础 中风后轻偏瘫的患者。本计划提供的指导将有助于指导 作为一名独立的调查员，并为候选人的长期工作取得重大进展， 长期研究目标是了解人类运动过程中的肢体间协调以及 神经损伤后运动功能的恢复。 相关性：这项研究将对公共卫生产生广泛的影响，因为中风是导致长期死亡的主要原因。 长期残疾，使许多受害者在没有帮助的情况下无法行走（AHA 2005年）。的结果 这些研究有望有助于开发针对中风康复的新疗法。 尤其是步态恢复。

PROJECT SUMMARY: The purpose of this Mentored Research Scientist Development Award is to prepare the candidate for a successful long-term career in medical rehabilitative research. The candidate will receive primary sponsorship from a senior-level scientist who will provide the candidate with a period of intensive, focused training in the areas of motor cortical neurophysiology, motor cortical plasticity following stroke, and the use of transcranial magnetic stimulation as a research tool to measure cortical excitability. The purpose of the research proposed here is to determine mechanisms of bilateral leg control in individuals with post- stroke hemiparesis; specifically, to determine the effects of the sensorimotor state of one leg on the motor behavior of the opposite leg. Three studies will be undertaken to determine: 1) does damage to the motor cortex cause specific deficits in bilateral more than unilateral cyclical ankle movements? 2) to what extent do ipsilateral uncrossed corticospinal pathways contribute to unilateral and bilateral cyclical ankle movements in individuals with motor cortical stroke? and 3) does damage to the motor cortex impair bilateral leg motor responses to a novel unilateral perturbation during walking? To answer these questions, 3-D movement kinematics and electromyography will be recorded from subjects with hemiparesis caused by motor cortical stroke and healthy age- and gender-matched control subjects performing ankle movement tasks and walking. Results will help explain the specific function of the motor cortex and corticospinal pathway and will provide a basis for the development of novel rehabilitation techniques to recover normal locomotor function in individuals with post-stroke hemiparesis. The mentorship provided in this plan will help direct the candidate toward independence as an investigator and lend significant progress toward the candidate's long- term research goal of understanding interlimb coordination during human locomotion and mechanisms for recovery of locomotor function following neurological damage. RELEVANCE: This research will have broad impact on public health, as stroke is a leading cause of long- term disability and leaves many of its victims unable to walk without assistance (AHA 2005). Findings from these studies are expected to help lead to the development of new treatments aimed at stroke rehabilitation generally and gait recovery specifically.