Quadriceps inhibition after ACL injury: Neuromuscular and functional consequences

ACL 损伤后股四头肌抑制：神经肌肉和功能后果

基本信息

批准号：
7614421
负责人：
Riann Marie Palmieri-Smith
金额：
$ 12.69万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-04-18 至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7614421
关键词：
Address Adopted Anterior Cruciate Ligament Area Athletic Attention Award Biomechanics Chronic Clinical Clinical Research Control Groups Data Deceleration Degenerative polyarthritis Development Dose Electric Stimulation Evolution Exhibits Feasibility Studies Fire - disasters Functional disorder Future Goals Guidelines Human Resources Humulus Impairment Incidence Injury Intervention Joints Kinetics Knee Knee joint Knowledge Laboratories Lead Ligaments Limb structure Literature Lower Extremity Measures Mechanics Mechanoreceptors Motion Muscle Natural regeneration Nature Neural Inhibition Outcome Pain Participant Patient Selection Patients Pattern Performance Persons Plant Roots Play Postoperative Period Preparation Process Protocols documentation Randomized Clinical Trials Randomized Controlled Trials Reaction Reconstructive Surgical Procedures Recovery of Function Rehabilitation therapy Research Research Design Research Personnel Residual state Risk Scientist Secondary to Simulate Skeletal Muscle Structure Techniques Testing Time Training Translating United States Work anterior cruciate ligament reconstruction anterior cruciate ligament rupture base clinical practice clinically relevant design effusion experience functional outcomes improved injured investigator training joint injury kinematics ligament injury neuromuscular prevent programs reconstruction repaired research study response restraint

项目摘要

DESCRIPTION (provided by applicant): The rationale for this application is to allow Dr. Riann Palmieri-Smith to receive both the didactic training and practical research experience necessary for her evolution into an independent clinical research scientist. This award will provide her with an opportunity to complete coursework in the areas of biomechanics and clinical research design. Dr. Palmieri-Smith will conduct clinical research, under the direction of Drs. Ashton-Miller, Sowers, and Wojtys examining the impact of quadriceps inhibition on knee mechanics and will also examine the feasibility of introducing neuromuscular electrical stimulation (NMES) as an adjunct to ACL rehabilitation. Building on the experience gathered during the period of this award, Dr. Palmieri-Smith will use the information she obtains from mechanistic, laboratory-based studies to develop and test clinical interventions that can improve the neuromuscular and functional recovery of persons following traumatic knee joint injury and those with osteoarthritis. The proposed research will determine the magnitude of quadriceps inhibition necessary to result in biomechanical, functional, and neuromuscular adaptations, and the feasibility of introducing NMES, an intervention capable of restoring quadriceps activation, in rehabilitation post-ACL reconstruction to restore normal mechanics. The burst superimposition technique will be utilized in subsets of ACL reconstructed patients to estimate quadriceps inhibition prior to and following ACL reconstruction and prior to and following NMES. Mechanics will be examined during a onelegged forward hop. RELEVANCE: Quadriceps inhibition is present following ACL injury and reconstruction and often persists for years following repair and its consequences remain elusive. Our work will allow for a better understanding of how muscle dysfunction impacts joint protective mechanisms. Introducing NMES as an adjunct to ACL rehabilitation may promote sustained improvements in quadriceps activation thereby restoring lower extremity mechanics and potentially reducing the incidence of post-traumatic osteoarthritis. This knowledge will aid clinicians in designing appropriate rehabilitation protocols and return to play guidelines that will prevent future injury and joint degeneration.

描述（由申请人提供）：本申请的理由是允许Riann Palmieri-Smith博士获得教学培训和实践研究经验，而这是她发展为独立临床研究科学家所必需的。该奖项将为她提供在生物力学和临床研究设计领域完成课程的机会。 Palmieri-Smith博士将在DRS的指导下进行临床研究。 Ashton-Miller，Sowers和Wojtys检查了股四头肌抑制对膝盖力学的影响，还将检查引入神经肌肉电刺激（NMES）作为ACL康复的辅助性的可行性。在此奖项期间收集的经验的基础上，Palmieri-Smith博士将使用她从机械，基于实验室的研究中获得的信息来开发和测试临床干预措施，以改善创伤性膝关节损伤后的人的神经肌肉和功能恢复，并患有骨关节炎。拟议的研究将确定股四头肌抑制的大小，以导致生物力学，功能和神经肌肉适应，以及引入NME的可行性，NME的可行性，NME（一种能够恢复股四头肌激活的干预措施，用于恢复后的恢复后 - 重建后重建以恢复正常的机制。爆发叠加技术将用于ACL重建患者的子集，以估计ACL重建之前和之后的股四头肌抑制作用以及在NME之前和之后进行的。将在一个远程前的啤酒花中检查机制。相关性：ACL损伤和重建后存在股四头肌抑制作用，并且在修复后经常持续数年，其后果仍然难以捉摸。我们的工作将可以更好地了解肌肉功能障碍如何影响关节保护机制。引入NME作为ACL康复的辅助手段可能会促进股四头肌激活的持续改善，从而恢复下肢力学，并可能降低创伤后骨关节炎的发生率。这些知识将有助于临床医生设计适当的康复方案，并恢复播放指南，以防止未来的伤害和联合退化。