EARLY INNATE IMMUNE RESPONSE IN DENGUE VIRUS INFECTION

登革热病毒感染的早期先天免疫反应

• 批准号: 7715823
• 负责人: GUEY-CHUEN PERNG
• 金额: $ 2.85万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715823
• 关键词: Blood Platelets; Computer Retrieval of Information on Scientific Projects Database; Dengue Virus; Event; Funding; Grant; Human; Immune response; Infection; Institution; Investigation; Lead; Macaca; Macaca mulatta; Megakaryocytes; Modeling; Monkeys; Pathology; Predisposition; Protocols documentation; Reporting; Research; Research Personnel; Resources; Serotyping; Source; Symptoms; Syndrome; United States National Institutes of Health; Virus; Virus Diseases; Week; interest; man

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aims of this pilot protocol are to document the early dissemination and pathology of DENGUE virus infection in rhesus macaques. Human infection with Dengue virus is generally detected about one week post infection and there is therefore a dearth of information on the early event of virus infection in a model close to man. Although monkeys have not been reported to be susceptible to the hemorrhagic syndrome associated with Dengue virus infection or reinfection, macaques are nevertheless susceptible to infection with viruses from all 4 serotypes. Of particular interest in this investigation will be the susceptibility of megakaryocytes and platelets to viral infection as their early destruction may potentially lead to hemorrhagic symptoms.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本试验方案的目的是记录恒河猴中登革病毒感染的早期传播和病理学。人类感染登革病毒通常在感染后一周左右被检测到，因此在接近人类的模型中缺乏关于病毒感染早期事件的信息。尽管尚未报道猴子对与登革病毒感染或再感染相关的出血综合征易感，但猕猴对所有4种血清型的病毒感染均易感。本研究中特别感兴趣的是巨核细胞和血小板对病毒感染的易感性，因为它们的早期破坏可能导致出血症状。