Molecular Genetics of Speciation Driven by Intragenomic Conflicts

基因组内冲突驱动的物种形成的分子遗传学

• 批准号: 7787527
• 负责人: Yun Tao
• 金额: $ 31.84万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7787527
• 关键词: Alleles; Chromosomes; Chromosomes, Human, 13-15; Conflict (Psychology); Development; Drosophila genus; Evolution; Failure; Fertility; Follow-Up Studies; Gametogenesis; Genes; Genetic; Genome; Goals; Hybrids; Laboratories; Link; Male Sterility; Maps; Meiosis; Methods; Molecular; Molecular Genetics; Mutate; Mutation; Nature; Paris, France; Pattern; Phenotype; Population; Process; RNA Interference; Research; Sequence Homology; Sex Chromosomes; Sex Ratio; Siblings; Small RNA; Staging; Sterility; System; Technology; Testing; Transgenic Organisms; Work; X Chromosome; autosome; expectation; loss of function; male; member; positional cloning; public health relevance; reproductive; segregation; sex; sperm cell; theories

DESCRIPTION (provided by applicant): Speciation is the process by which an interbreeding population becomes divided into reproductively isolated groups. The long-term research goal in our laboratory is to test the hypothesis that the first steps toward postzygotic reproductive isolation are due to the evolution of sex-ratio meiotic drive systems. Sex- ratio meiotic drive is a phenomenon of non-Mendelian segregation manifested by genetic conflicts between sex chromosomes and autosomes. In the proposed research, we shall characterize genes involved in meiotic drive and/or hybrid male sterility. First, we will study the Winter sex-ratio for the molecular mechanisms involved for this system through small RNA profiling and transgenics. Second, we will study the Durham sex-ratio to characterize the hybrid male sterility loci that are either member of or interacting with this sex-ratio system. In the end, we expect to determine the molecular and evolutionary link between meiotic drive and speciation. PUBLIC HEALTH RELEVANCE: Speciation is the process by which an interbreeding population becomes divided into reproductively isolated groups. We propose to determine the molecular and evolutionary link between meiotic drive, a form of genetic conflicts within a genome, and speciation.

描述（由申请人提供）：物种是将杂交种群分为生殖孤立组的过程。我们实验室中的长期研究目标是检验以下假设：迈向期生殖后隔离的第一步是由于性别比例减数分裂驱动系统的发展。性比率减数分裂驱动是非孟德尔隔离的现象，该现象是由性染色体和常染色体之间的遗传冲突所表现出来的。在拟议的研究中，我们将表征与减数分裂驱动和/或杂交男性无菌性有关的基因。首先，我们将通过小的RNA分析和转基因研究来研究该系统所涉及的分子机制。其次，我们将研究达勒姆性比例，以表征与这种性比率系统相互作用或与此相互作用的混合性男性不育基因座。最后，我们期望确定减数分裂驱动与物种形成之间的分子和进化联系。公共卫生相关性：物种形成是杂交种群分为生殖孤立的群体的过程。我们建议确定减数分裂驱动（基因组中的遗传冲突形式）与物种形成之间的分子和进化联系。