Molecular Genetics of Speciation Driven by Intragenomic Conflicts

基因组内冲突驱动的物种形成的分子遗传学

• 批准号: 8241160
• 负责人: Yun Tao
• 金额: $ 30.57万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8241160
• 关键词: Alleles; Chromosomes; Chromosomes, Human, 13-15; Conflict (Psychology); Development; Drosophila genus; Evolution; Failure; Fertility; Gametogenesis; Genes; Genetic; Genome; Goals; Health; Hybrids; Laboratories; Link; Male Sterility; Maps; Meiosis; Methods; Molecular; Molecular Genetics; Mutate; Mutation; Nature; Paris, France; Pattern; Phenotype; Population; Process; RNA Interference; Research; Sequence Homology; Sex Chromosomes; Sex Ratio; Siblings; Small RNA; Staging; Sterility; System; Technology; Testing; Transgenic Organisms; Work; X Chromosome; autosome; expectation; follow-up; loss of function; male; member; positional cloning; reproductive; segregation; sex; sperm cell; theories

DESCRIPTION (provided by applicant): Speciation is the process by which an interbreeding population becomes divided into reproductively isolated groups. The long-term research goal in our laboratory is to test the hypothesis that the first steps toward postzygotic reproductive isolation are due to the evolution of sex-ratio meiotic drive systems. Sex- ratio meiotic drive is a phenomenon of non-Mendelian segregation manifested by genetic conflicts between sex chromosomes and autosomes. In the proposed research, we shall characterize genes involved in meiotic drive and/or hybrid male sterility. First, we will study the Winter sex-ratio for the molecular mechanisms involved for this system through small RNA profiling and transgenics. Second, we will study the Durham sex-ratio to characterize the hybrid male sterility loci that are either member of or interacting with this sex-ratio system. In the end, we expect to determine the molecular and evolutionary link between meiotic drive and speciation. PUBLIC HEALTH RELEVANCE: Speciation is the process by which an interbreeding population becomes divided into reproductively isolated groups. We propose to determine the molecular and evolutionary link between meiotic drive, a form of genetic conflicts within a genome, and speciation.

描述（由申请人提供）：物种形成是将杂交种群划分为生殖隔离组的过程。我们实验室的长期研究目标是检验这一假设，即合子后生殖隔离的第一步是由于性比减数分裂驱动系统的进化。性比减数分裂驱动是一种非孟德尔分离现象，表现为性染色体和常染色体之间的遗传冲突。在拟议的研究中，我们将表征参与减数分裂驱动和/或杂交雄性不育的基因。首先，我们将通过小RNA分析和转基因研究该系统所涉及的分子机制的冬季性别比。其次，我们将研究达勒姆性比，以表征杂交雄性不育基因座，无论是成员或与这个性比系统的相互作用。最后，我们期望确定减数分裂驱动和物种形成之间的分子和进化联系。公共卫生相关性：物种形成是一个杂交种群被分成生殖隔离群体的过程。我们建议确定减数分裂驱动（基因组内的一种遗传冲突形式）与物种形成之间的分子和进化联系。

项目成果

Sex ratio meiotic drive as a plausible evolutionary mechanism for hybrid male sterility.

• DOI: 10.1371/journal.pgen.1005073
• 发表时间: 2015-03
• 期刊: PLoS genetics
• 影响因子: 4.5
• 作者: Zhang L;Sun T;Woldesellassie F;Xiao H;Tao Y
• 通讯作者: Tao Y