Controlling the adhesome to regulate cell fate on biomaterials

控制粘附体来调节生物材料上的细胞命运

• 批准号: DP140104217
• 负责人: Prof Justin Cooper-White
• 金额: $ 25.55万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140104217
• 关键词: Controlling; adhesome; regulate; cell; fate

Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to rapidly, at high resolution, elucidate how mechanotransductive cues determine the fate choice of mesenchymal stem cells, and furthermore, how to manipulate them with smart biomaterial design to achieve desired outcomes for tissue engineering.

间充质干细胞为基础的组织工程的做法是世界各地的阻碍缺乏赞赏和理解的基质介导的线索，必须提供在粘附和蔓延，以驱动细胞到明确的组织终点。该项目将通过结合高通量阵列技术，一组可定制的自组装生物材料和实时生物传感器来解决这些知识不足，以快速，高分辨率阐明机械转导线索如何决定间充质干细胞的命运选择，以及如何用智能生物材料设计操纵它们以实现组织工程的预期结果。