Mimicking the perivascular niche with boronolectin-based biomaterials

该项目旨在通过发现在延长培养过程中提高细胞质量结果的新机制和材料来解决血管周围干细胞制造中的障碍。一种创新的、跨学科的生物材料发现方法，结合基于活细胞的细胞表面聚糖筛选、生物启发材料设计和合成以及生态位模仿，将有助于发现细胞表面聚糖介导的相互作用，支持长期扩张和效力维持，以及可以模仿它们的合成生物材料。干细胞研究人员、制造商和最终用户有望从该项目和这种可扩展的生物材料平台的应用中获益。

This project aims to address roadblocks in perivascular stem cell manufacturing by discovering novel mechanisms and materials that improve cell quality outcomes during extended culture. An innovative, interdisciplinary approach to biomaterials discovery, combining live cell-based screening of cell surface glycans, bio-inspired materials design and synthesis, and niche mimicry, will enable the discovery of cell surface glycan-mediated interactions that support long-term expansion and potency maintenance, and synthetic biomaterials that can mimic them. Significant benefits for stem cell researchers, manufacturers and end users are expected from the project and the application of this scalable biomaterial platform.