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Inflammation and platelet activation

Inflammation and platelet activation
炎症和血小板活化
批准号:
7619999
负责人:
Craig Fletcher
金额:
$155.66万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-05-01 至 2012-04-30
关键词:
AccountingAddressAdhesionsAffectAfrican AmericanAgingAmputationArchivesArterial Fatty StreakArteriesAtherosclerosisBaltimoreBindingBiologicalBiological FactorsBiological MarkersBiological ProcessBlood PlateletsBlood VesselsBrainCX3CL1 geneCXCR3 geneCardiovascular DiseasesCardiovascular systemCarotid ArteriesCaucasiansCaucasoid RaceCell LineCellsChemokine Receptor GeneChemotaxisClassClinicalCohort StudiesCollaborationsComplexConditionCoronary arteryCytoplasmic GranulesDNADNA RepairDNA SequenceDataDevelopmentDiseaseDisease OutcomeEmbolismEndothelial CellsEndotheliumEnhancersEnvironmentEnvironmental ExposureEthnic OriginEthnic groupEvolutionExocytosisFractalkineGangreneGenderGene FrequencyGenesGenetic PolymorphismGerontologyGoalsHaplotypesHealthHeart RateHigh PrevalenceImmuneImmune responseImmune systemInfectious AgentInflammationInflammatoryInflammatory ResponseInstitutesInstitutionIntermittent ClaudicationInternationalIschemiaKidney FailureLaboratoriesLeadLesionLeukocyte TraffickingLeukocytesLinkLinkage DisequilibriumLiteratureLongevityLower ExtremityMeasurementMeasuresMediatingMediator of activation proteinMethylationMissionModelingMolecular and Cellular BiologyMyocardial InfarctionMyocardiumNeighborhoodsNucleic Acid Regulatory SequencesOhioOxidative StressOxygenP-SelectinPainPatternPeripheral Vascular DiseasesPhasePhysiologic pulsePilot ProjectsPlatelet ActivationPlatelet Factor 4PlayPopulationPredispositionPrincipal InvestigatorProcessPropertyProtein IsoformsProteinsPublishingPulse takingResearchResearch PersonnelRiskRisk FactorsRoleRuptureScienceSecondary HypertensionSelectinsSerumSerum MarkersSeveritiesSingle Nucleotide PolymorphismSiteSocial BehaviorSocioeconomic FactorsSocioeconomic StatusSpecimenStagingStrokeSurrogate MarkersTestingTherapeuticThickThrombosisTissuesTravelTumor Necrosis Factor-alphaUniversitiesVariantarterial stiffnessatherogenesiscardiovascular disorder riskchemokinechemokine receptorcytokinedesignethnic differencehealth disparityhealthy aginghuman CX3CR1 proteinhuman TNF proteininterestleukocyte proliferationmacrophagemonocytenovelpromoterracial differencereceptorrenal arteryresponsesocial

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hypothesis that race differences in socio-environmental exposures lead to a pro-inflammatory predisposition which can in turn lead to an increased risk of cardiovascular disease. This study will be conducted using data from the HANDLS (Healthy Aging in Neighborhoods of Diversity across the Life Span study), a study conducted by National Institution on Aging, Laboratory of Cellular and Molecular Biology of the Gerontology Research Center. This study is designed to merge biological, behavior, and social determinants of health disparities without confounding from socioeconomic status.
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Inflammation and platelet activation
  • 批准号:
    7314617
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    2007
  • 负责人:
    Craig Fletcher
  • 依托单位:
Inflammation and platelet activation
  • 批准号:
    7828104
  • 项目类别:
  • 资助金额:
    $63.29万
  • 财政年份:
    --
  • 负责人:
    Craig Fletcher
  • 依托单位:
Inflammation and platelet activation
  • 批准号:
    8072663
  • 项目类别:
  • 资助金额:
    $63.96万
  • 财政年份:
    --
  • 负责人:
    Craig Fletcher
  • 依托单位:
Inflammation and platelet activation
  • 批准号:
    8300045
  • 项目类别:
  • 资助金额:
    $66.21万
  • 财政年份:
    --
  • 负责人:
    Craig Fletcher
  • 依托单位:
海外基金