Human Subjects Core: Protocols, Statistics, Collaborative Method Development and

跨学科和转化性临床研究的开展是复杂的，可以优化。 通过协调各项目的专门资源。这本P30将提供核心人类科目 跨临床研究和统计分析的协调和高效数据收集和统计分析的资源 该联合体中包括的试点项目。在IRCSSA的总体目标中，需要好好学习 在所有人类项目中确定临床和非临床参与者的特征，从而实现 量表，更重要的是综合关于压力、自我控制和成瘾的研究结果 响应系统。这可以通过协调和集中的参与者招聘过程来实现 并通过使用类似的方法来理解压力、自我控制和成瘾的关键概念 跨研究项目。此外，作为多系统评估(例如，遗传学、神经化学、 生理、行为、社会因素)正在进行多项研究，我们计划创建大型 临床和非临床参与者组的通用测量数据集，以评估关键 从多个角度构建。以这种方式，结合了这些服务的人类受试者P30 将加强IRCSSA中人类项目之间的协同作用。因此，这个核心的总体目标是 (1)为临床研究的学科招募提供中央统筹；(2) 提供关于压力、自我控制、身体健康筛查措施的中央评估资源 吸烟、饮酒、暴饮暴食等特定成瘾行为；(3)提供中央数据收集和 管理资源；(4)提供集中和协调的数据分析和统计专门知识； (5)为正在进行的和试点研究的调查人员提供科学支持和咨询。穿过 这些目标P30将为人体研究提供关键支持，并促进数据整合 IRCSSA中的项目。这种集成将允许跨研究的汇集分析，这将导致更多 全面了解成瘾时影响自我控制过程的压力机制。

The conduct of interdisciplinary and translational clinical research is complex and can be optimized through coordination of specialized resources across projects. This P30 will provide core Human Subjects resources for coordinated and efficient data collection and statistical analysis across the clinical studies and pilot projects included in this consortium. Among the overall goals of the IRCSSA, is the need to study well characterized clinical and non-clinical participants in all human projects so as to achieve both economics of scale and more importantly to synthesize findings on stress, self control and addiction across multiple response systems. This may be achieved by a coordinated and centralized participant recruitment process and by the use of analogous measures to understand the key concepts of stress, self control and addiction across research projects. Furthermore, as multi-system assessments (e.g., genetics, neurochemical, physiological, behavioral, social factors) are being conducted across studies, we plan to create large datasets of common measures across clinical and non-clinical participant groups so as to evaluate the key constructs from multiple perspectives. In this way a Human Subjects P30 that incorporates these services will enhance the synergy between human projects in the IRCSSA. Therefore, the overall aims of this Core are the following: (1) To provide centralized coordination of subject recruitment for clinical studies; (2) To provide a central assessment resource on stress, self control, physical health screening measures and for specific addictive behaviors of smoking, drinking, overeating; (3) To provide central data collection and management resources; (4) To provide centralized and coordinated data analysis and statistics expertise; and (5) To provide scientific support and consultation to ongoing and pilot study investigators. Through these aims the P30 will provide critical support to the human studies and facilitate integration of data across projects in the IRCSSA. Such integration will permit pooled analysis across studies that will lead to a more comprehensive understanding of the stress mechanisms that affect self control processes in addiction.