Molecular markers of relapse and treatment response in ovarian cancer

卵巢癌是一种复杂的疾病，长期生存率一般较差。对初始治疗的反应通常很高，但大多数妇女复发，通常在2年内。对化疗的反应是多变的，难以预测。该项目将重点研究卵巢癌复发的原因，特别是在最初的良好反应之后；了解哪些特征决定了患者复发后对化疗的反应；以及提高化疗反应的策略。

Ovarian cancer is a complex disease with generally poor long-term survival. Response to initial treatment is generally high however most women relapse, usually within 2 years. Response to chemotherapy is variable and difficult to predict. This project will focus on why ovarian cancer recurs, especially after a good initial response; on understanding what features determine response to chemotherapy once patients have relapsed; and on strategies to increase response to chemotherapy.