Molecular markers of relapse and treatment response in ovarian cancer

卵巢癌复发和治疗反应的分子标志物

• 批准号: nhmrc : 1023952
• 负责人: Prof Anna Defazio
• 金额: $ 35.98万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-markers-relapse-ovarian-cancer/110309
• 关键词: Molecular; markers; relapse; treatment; response

Ovarian cancer is a complex disease with generally poor long-term survival. Response to initial treatment is generally high however most women relapse, usually within 2 years. Response to chemotherapy is variable and difficult to predict. This project will focus on why ovarian cancer recurs, especially after a good initial response; on understanding what features determine response to chemotherapy once patients have relapsed; and on strategies to increase response to chemotherapy.

卵巢癌是一种复杂的疾病，长期存活率普遍较低。对初始治疗的反应率一般很高，但大多数妇女通常在两年内复发。对化疗的反应是多变的，很难预测。这个项目将集中于卵巢癌复发的原因，特别是在良好的初始反应之后；了解一旦患者复发，哪些特征决定了对化疗的反应；以及提高对化疗反应的策略。