METABOTROPIC GLUTAMATE RECEPTOR MECHANISMS IN COCAINE ABUSE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 谷氨酸被认为在与滥用可卡因有关的行为影响中起着不可或缺的作用。本项目调查特定的代谢型谷氨酸受体亚型在持续的可卡因滥用中的作用。定量药理学和行为技术为机制分析和确定药物治疗的新靶点提供了一个经验框架。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Glutamate is believed to play an integral role in the behavioral effects of cocaine related to its abuse. This project investigates the roles of specific metabotropic glutamate receptor subtypes in persistent cocaine abuse. Quantitative pharmacological and behavioral techniques provide an empirical framework for mechanistic analysis and identifying novel targets for pharmacotherapy.