METABOTROPIC GLUTAMATE RECEPTOR MECHANISMS IN COCAINE ABUSE

可卡因滥用中的代谢型谷氨酸受体机制

• 批准号: 7715462
• 负责人: DONNA M PLATT
• 金额: $ 1.08万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-05 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715462
• 关键词: Behavioral; Cocaine; Cocaine Abuse; Computer Retrieval of Information on Scientific Projects Database; Funding; Glutamates; Grant; Institution; Metabotropic Glutamate Receptors; Pharmacotherapy; Play; Research; Research Personnel; Resources; Role; Source; Techniques; United States National Institutes of Health; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Glutamate is believed to play an integral role in the behavioral effects of cocaine related to its abuse. This project investigates the roles of specific metabotropic glutamate receptor subtypes in persistent cocaine abuse. Quantitative pharmacological and behavioral techniques provide an empirical framework for mechanistic analysis and identifying novel targets for pharmacotherapy.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 谷氨酸被认为在与可卡因滥用有关的行为效应中起着不可或缺的作用。 本项目研究特定的代谢型谷氨酸受体亚型在持续性可卡因滥用中的作用。 定量药理学和行为学技术为机制分析和确定药物治疗的新靶点提供了一个经验框架。