SUBJECTIVE/REINFORCING EFFECTS OF HEROIN-BENZODIAZEPINE COMBINATIONS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。大量的临床数据表明，阿片成瘾者经常在海洛因或美沙酮维持治疗的同时滥用苯二氮类药物(BZS)。最近的研究表明，这种形式的多药滥用反映了BZS增强了海洛因和其他阿片类激动剂的滥用相关影响。在被训练来区分海洛因和生理盐水的恒河猴身上，传统的非选择性BZ三唑仑与海洛因没有区别的刺激效应。此外，当两种药物联合使用时，如果剂量低于控制率的50%，则两种药物之间不存在相互作用。在恒河猴中，按照静脉注射的累进比率计划进行训练。注射毒品后，海洛因和常规的BZ劳拉西潘均保持剂量依赖和可靠的自我给药。初步研究表明，相对较低剂量的海洛因与低剂量的劳拉西潘联合使用，与单独服用任何一种药物相比，自我给药的数量都有显著增加。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. An extensive body of clinical data indicates that opioid addicts regularly abuse benzodiazepines (BZs) in conjunction with heroin or methadone maintenance therapy. Recent research suggests that this form of polydrug abuse reflects an enhancement of the abuse-related effects of heroin and other opioid agonists by BZs. In rhesus monkeys trained to discriminate heroin from saline, the conventional non-selective BZ triazolam did not share discriminative stimulus effects with heroin. Furthermore, there was no interaction between the two drugs when administered in combination up to doses that reduced rates of responding below 50 per cent of control rates. In rhesus monkeys trained under a progressive ratio schedule of i.v. drug injection, both heroin and the conventional BZ lorazepam maintained dose-dependent and reliable self-administration. Preliminary studies indicate that combining a relatively low dose of heroin with a low dose of lorazepam resulted in a significant increase in self-administration compared to either drug individually.