NEUROBIOLOGY OF PRIMATE SOCIAL BEHAVIOR

灵长类社会行为的神经生物学

• 批准号: 7715546
• 负责人: David G Amaral
• 金额: $ 8.13万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715546
• 关键词: Acoustics; Adult; Age; Amygdaloid structure; Animal Behavior; Behavior; Brain; Computer Retrieval of Information on Scientific Projects Database; Development; Fright; Funding; Genetic; Grant; Hippocampus (Brain); Ibotenic Acid; Image; Infant; Institution; Investigation; Lesion; Macaca; Maternal Behavior; Methods; Monkeys; Neurobiology; Primates; Process; Protocols documentation; Research; Research Personnel; Resources; Role; Social Behavior; Social Interaction; Source; United States National Institutes of Health; Week; frontal lobe; mature animal; prepulse inhibition; relating to nervous system

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Specific Aims of this project are as follows: Specific Aim 1  To continue investigations of the socioemotional development of monkeys who received ibotenic acid lesions of the amygdala or hippocampus at two weeks of age. Specific Aim 2  To evaluate the sexual and maternal behavior in monkeys who received ibotenic acid lesions of the amygdala or hippocampus at two weeks of age. Specific Aim 3  To use acoustic startle tasks such as fear potentiated startle and prepulse inhibition to investigate the effect of permanent lesions and transient inactivation of the amygdala on components processes of fear behavior. Specific Aim 4  To use microPET imaging to examine brain plasticity resulting from ibotenic acid lesions of the amygdala in the adult and infant monkeys. Specific Aim 5  To use microPET imaging to investigate potential neural substrates for increased fear behavior by animals who received amygdala lesions as infants during dyadic social interactions and for increased social behavior for adult animals with amygdala lesions. Specific Aim 6  To use a genetic method for reversible inactivation of the amygdala to replicate the effects of permanent amygdala lesions on socioemotional behavior. Specific Aim 7  To use protocols developed to investigate social behavior in the macaque monkey during the current funding period to investigate the roles of two regions of the frontal lobe in social behavior.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目的具体目标如下： 具体目标 1 继续研究两周龄时杏仁核或海马接受鹅膏菌酸损伤的猴子的社会情感发展。 具体目标 2 评估两周龄接受鹅膏蕈酸杏仁核或海马损伤的猴子的性行为和母性行为。 具体目标 3 使用声音惊吓任务（例如恐惧增强惊吓和前脉冲抑制）来研究杏仁核的永久性损伤和短暂失活对恐惧行为组成过程的影响。 具体目标 4 使用 microPET 成像检查成年猴和幼猴杏仁核鹅黄酸损伤导致的大脑可塑性。 具体目标 5 使用 microPET 成像来研究婴儿期杏仁核损伤动物在二元社交互动期间恐惧行为增加的潜在神经基质，以及杏仁核损伤成年动物社交行为增加的潜在神经基质。 具体目标 6 使用遗传方法使杏仁核可逆失活，以复制永久性杏仁核损伤对社会情绪行为的影响。 具体目标 7 在当前资助期间，使用为调查猕猴社会行为而开发的方案来调查额叶两个区域在社会行为中的作用。