DEVELOPMENT OF ALLERGY-PREVENTIVE NOSE DROPS FOR USE IN EARLY INFANCY

开发用于婴儿早期的防过敏滴鼻剂

• 批准号: 7715649
• 负责人: BO L LONNERDAL
• 金额: $ 2.71万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715649
• 关键词: Adolescent; Affect; Child; Chronic Disease; Computer Retrieval of Information on Scientific Projects Database; Development; Drops; Food Hypersensitivity; Funding; Grant; Health; Human; Hypersensitivity; Immune system; Infant; Institution; Methods; Microbe; Newborn Infant; Nose; Preventive; Research; Research Personnel; Resources; Societies; Source; T-Lymphocyte; United States National Institutes of Health; infancy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective is to develop an allergy preventive treatment. We have observed that newborn human infants naturally exposed to certain immuno-stimulating bacterial products have not developed food allergy. In these infants, we also noted expansion of regulatory T cells. Allergy is a major chronic disease of children and adolescents in Western societies, affecting up to one third of all children. Allergies are a form of dysregulation of the immune system which many believe is due to lack of stimulation by microbes in infancy. If an allergy preventive method can be developed, the positive health consequences are enormous.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的是开发一种预防过敏的治疗方法。我们已经观察到，自然暴露于某些免疫刺激细菌产品的新生人类婴儿没有发生食物过敏。在这些婴儿中，我们还注意到调节性T细胞的扩增。过敏症是西方社会儿童和青少年的一种主要慢性疾病，影响到所有儿童的三分之一。过敏是免疫系统失调的一种形式，许多人认为这是由于婴儿期缺乏微生物的刺激。如果能够开发出一种预防过敏的方法，积极的健康后果是巨大的。