COGNITIVE FUNCTION IN THE AGED MONKEY

老年猴子的认知功能

• 批准号: 7715565
• 负责人: PETER R RAPP
• 金额: $ 18.22万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715565
• 关键词: Cognitive aging; Computer Retrieval of Information on Scientific Projects Database; Female; Funding; Grant; Hormones; Impairment; Individual Differences; Institution; Macaca mulatta; Memory; Monkeys; Ovarian hormone; Procedures; Research; Research Personnel; Resources; Source; Testing; United States National Institutes of Health; age related; aged; cognitive function; design; memory process; neuropsychological; pathological aging; urinary

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: The overall aims of the project are to define the effects of normal, non-pathological aging on the component processes of memory, and to evaluate these changes in relation to markers of ovarian hormone impairment in rhesus monkeys. Groups of young and aged subjects are tested across a battery of well-studied, standardized neuropsychological tasks as well as newly developed procedures designed to provide a sensitive window on cognitive aging. Urinary hormone profiles are determined for all female monkeys periodically throughout the project in order to relate these parameters to individual differences in the status of age-related memory decline.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：该项目的总体目标是确定正常的非病理性衰老对记忆组成过程的影响，并评估这些变化与恒河猴卵巢激素损伤标志物的关系。年轻和老年受试者的群体进行了测试，在电池的充分研究，标准化的神经心理学任务，以及新开发的程序，旨在提供一个敏感的窗口认知老化。在整个项目中定期测定所有雌性猴的尿激素谱，以将这些参数与年龄相关记忆衰退状态的个体差异相关联。