COGNITIVE FUNCTION IN THE AGED MONKEY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。该项目的总体目标是确定正常、非病理性衰老对记忆组成过程的影响，并评估这些变化与恒河猴卵巢激素损伤标志物的关系。一组年轻和年老的受试者通过一系列经过充分研究的标准化神经心理学任务以及新开发的程序进行测试，这些程序旨在为认知衰老提供一个敏感的窗口。在整个项目中，为了将这些参数与年龄相关的记忆衰退状态的个体差异联系起来，对所有雌性猴子的尿激素谱进行了定期测定。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall aims of the project are to define the effects of normal, non-pathological aging on the component processes of memory, and to evaluate these changes in relation to markers of ovarian hormone impairment in rhesus monkeys. Groups of young and aged subjects are tested across a battery of well-studied, standardized neuropsychological task as well as newly developed procedures designed to provide a sensitive window on cognitive aging. Urinary hormone profiles are determined for all female monkeys periodically throughout the project in order to relate these parameters to individual differences in the status of age-related memory decline.