K23 NEURODEVELOPMENTAL BIOLOGY IN PRESCHOOL CHILDREN

K23 学龄前儿童神经发育生物学

• 批准号: 7719584
• 负责人: EVE GARLINGTON SPRATT
• 金额: $ 1.55万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719584
• 关键词: Biology; Blood; Blood specimen; Brain; Cell Count; Child Behavior; Clinical; Computer Retrieval of Information on Scientific Projects Database; DNA; Endocrine system; Failure; Family; Funding; Future; Grant; Growth; Home environment; Hormones; Hour; Hydrocortisone; Informed Consent; Institution; Interview; Lead; Measures; Metabolic syndrome; Participant; Preschool Child; Psychological Tests; Purpose; Research; Research Personnel; Resources; Saliva; Salivary; Sampling; Source; Stress; Structure; Testing; Thyroid Function Tests; United States National Institutes of Health; Urine; Visit; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to better understand the biologic response to stress by the endocrine system. We hope that this study will lead to a better understanding of the relationship between stress hormones and the developing brain, and how these are related to child behavior and family stress. Participating in this study will require 2 visits with research personnel; one visit being completed at the participant's home, and one clinical visit to the GCRC. The first visit will occur after informed consent is signed and will include approximately two to three hours of structured interviewing questions. The GCRC visit will include psychological testing, 4 samples of saliva to measure salivary cortisol, and approximately 30 ml sample of blood to examine cortisol, cell count, thyroid function tests, lead levels, markers of metabolic syndrome, growth failure. In addition, urine and blood will be collected and stored for possible DNA testing in the future.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是为了更好地了解内分泌系统对应激的生物反应。我们希望这项研究将有助于更好地理解压力荷尔蒙和大脑发育之间的关系，以及它们与儿童行为和家庭压力的关系。 参与这项研究需要与研究人员进行两次访问；一次访问在参与者的家中完成，一次临床访问GCRC。第一次访问将在签署知情同意书后进行，将包括大约两到三个小时的有组织的面试问题。GCRC的访问将包括心理测试、4个唾液样本以测量唾液皮质醇，以及大约30毫升血液样本以检测皮质醇、细胞计数、甲状腺功能测试、铅水平、代谢综合征标记物和生长障碍。此外，还将收集和储存尿液和血液，以备将来可能进行的DNA检测。