SNP PROFILE OF RADIOSENSITIVE-RELEVANT GENES/ADVERSE REACTION IN PROSTATE CANCER

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 本研究的目的是调查遗传变异之间的关联，这些遗传变异影响非洲裔美国男性前列腺癌患者对放射治疗相关不良事件的易感性。PI假设，如果他们确定了与放疗相关不良事件相关的基因多态性，则有可能改变给予受试者的辐射剂量，以减少或消除这些不良事件。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is investigate the association between genetic variations that influence susceptibility to adverse events associated with radiation therapy in African-American men with prostate cancer. The PI hypothesizes that if they identify polymorphism in genes that correlate with adverse events associated with radiotherapy, it is possible to alter the radiation dose given to the subject to reduce or eliminate these adverse events.